Curcumin has been shown to have many potentially health beneficial properties in vitro and in animal models with clinical studies on the toxicity of curcumin reporting no major side effects. However, curcumin may chelate dietary trace elements and could thus potentially exert adverse effects. Here, we investigated the effects of a 6 month dietary supplementation with 0.2% curcumin on iron, zinc...

Total reduced sulfurs (TRS) include hydrogen sulfide (H2S), methyl mercaptan (methanethiol, CH3SH), dimethyl sulfide (CH3SCH3) and dimethyl disulfide (CH3S2CH3) and are referred to as noncondensible gases. They are part of a well-known environmental problem afflicting pulp mills exploiting the Kraft pulp mill process. These sulfur compounds are formed in the Kraft pulping process and come in co...

The synthesis, structure, and spectroscopic signatures of a series of four-coordinate iron(II) complexes of β-ketoiminates and their zinc(II) analogues are presented. An unusual five-coordinate iron(II) triflate with three oxygen bound protonated β-ketoimines is also synthesized and structurally characterized. Single-crystal X-ray crystallographic analysis reveals that the deprotonated bis(chel...

Red blood cells (RBCs) from patients with sickle cell anemia and thalassemia carry abnormal accumulations of molecular Fe(III) at the cytosol/membrane interface. The avidity of the red cell membrane for this iron has not been defined. Using open ghost membranes prepared from sickle RBC, we examined the ability of membrane-associated Fe(III) to resist removal by 15 chelators representing a 40-lo...

INTRODUCTION Uropathogenic Escherichia coli (UPEC), the causative agent of over 85% of urinary tract infections (UTIs), elaborate a number of siderophores to chelate iron from the host. On the other hand, the host immune imperative is to limit the availability of iron to the bacteria. Little is known regarding the mechanisms underlying this host-iron-UPEC interaction. Our objective was to deter...

Precious metal complexes with the d6 valence electron configuration often exhibit luminescent metal-to-ligand charge transfer (MLCT) excited states, which form basis for many applications in lighting, sensing, solar cells and synthetic photochemistry. Iron(ii) has received much attention as a possible Earth-abundant alternative, but to date no iron(ii) complex been reported show MLCT emission u...

Iron is an essential micronutrient but is toxic if accumulated at high levels. Thus, iron uptake and distribution in plants are controlled by precise regulatory mechanisms. IRON-REGULATED TRANSPORTER1 (IRT1) is the major high affinity iron transporter responsible for iron uptake from the soil in Arabidopsis (Arabidopsis thaliana). Previously, we showed that IRT1 is subject to posttranscriptiona...