Cancer continues to represent the largest cause of mortality in the world and claims over 6 million lives each year (Abdullaev et al., 2000). An extremely promising strategy for cancer prevention today is chemoprevention, which is defined as the use of synthetic or natural agents (alone or in combination) to block the development of cancer in human beings (Abdullaev et al., 2004).It is a hotspo...

background: there is much debate about effects of medicinal plants such as saffron (crocus sativus) on human health. women are highly involved in farming and processing of this plant. this study is aimed at evaluating the saffron impacts on miscarriage rate of female farmers working in saffron fields. methods: this was a prospective case-control study on pregnant female farmers during harvestin...

Saffron petal is the main by-product of saffron processing which produced at high level but it is not applied and thrown out. Saffron petal is containing of several compounds such as mineral agents, anthocyanins, flavonoids, glycosides, alkaloids and kaempferol. As saffron petal is cheaper and produces in large amounts compared to saffron stigma, so, it can be considered as an appropriate sourc...

BACKGROUND In the last two decades, pioneering research on anti-tumour activity of saffron has shed light on the role of crocetin, picrocrocin and safranal, as broad spectrum anti-neoplastic agents. However, the exact mechanisms have yet to be elucidated. Identification and characterization of the targets of bioactive constituents will play an imperative role in demystifying the complex anti-ne...

Background & aim: This systematic overview of reviews on complementary and alternative medicine (CAM) was performed to summarize the clinical efficacy of this approach in the treatment of erectile dysfunction (ED) and assess methodological quality of the included reviews. Methods: A comprehensive search was performed to find the systematic reviews and meta-analyses on CAM interventions (e.g., a...

Antimicrobial activities of methanolic and petroleum ether extracts of Croccus sativus L. (saffron) stigmas, were tested against various bacterial strains (Proteus vulgaris, Klebsiella pneumonia, Pseudomonas aeruginosa, Staphylococcus aureus and Escherichia coli) and fungi (Candida albicans, Aspergillus niger and Aspergillus fumigatus) by agar well diffusion method. Minimal inhibitory concentra...

background & aim: saffron is one of the expensive spices known since antiquity for its color, flavor and medicinal properties. saffron is the dried stigma of crocus sativus plant. the three basic components of the stigma on which the qualitative characteristics of saffron depend are crocin (color), picrocrocin (taste), and safranal (aroma). the quality of saffron is a function of climatic c...

Objective: There are different pathophysiological mechanisms for obsessive- compulsive disorder (OCD) as suggested by the serotonergic, dopaminergic, and glutamatergic hypotheses. The present study aimed at comparing the efficacy and safety of saffron (stigma of Crocus sativus) and fluvoxamine in the treatment of mild to moderate obsessive- compulsive disorder. Method: In this study, 50 males a...

Mitochondrial dysfunction is the key pathogenic mechanism of cerebral injury induced by high-altitude hypoxia. Some Chinese herbal monomers may exert anti-hypoxic effects through enhancing the efficiency of oxidative phosphorylation. In this study, effects of 10 kinds of Chinese herbal monomers on mitochondrial respiration and membrane potential of cerebral mitochondria isolated from hypoxia-ex...

Due to dynamic nature of current software development methods, changes in requirements are embraced and given proper consideration. However, this triggers the rank reversal problem which involves re-prioritizing requirements based on stakeholders’ feedback. It incurs significant cost because of time elapsed in large number of human interactions. To solve this issue, a Semi-Automated Framework f...