C4d is a degradation product of complement component C4. Since the beginning of the current century, C4d has been used as a marker of acute antibody mediated rejection in renal allograft and considered as an ominous portent for poor graft survival. The ninth Banff meeting emphasized the value of C4d in renal allograft biopsy assessment and adopted a grading system for the staining degree of C4d...

Endothelial deposition of the complement split product C4d is an established marker of antibody-mediated acute renal allograft rejection. A contribution of alloantibody-dependent immune reactions to chronic rejection is under discussion. In this study, the association of immunohistochemically detected endothelial C4d deposition in peritubular capillaries (PTC) with morphologic features of chron...

BACKGROUND An important role of TLR2 has been shown in various experimental models of renal ischaemia/reperfusion injury. To study the expression of TLR2 in renal allograft rejection systematically, we established an experimental rat transplantation model. METHODS TLR2 expression was analysed in 99 human renal allograft biopsies, and in rat allografts at Day 6 and 28 after experimental renal ...

Background: Accurate and rapid assessment of allograft function is essential in renal transplant recipients in order to detect allograft rejection and to monitor drug nephrotoxicity. We aimed to evaluate the usefulness of cystatin C as a marker of kidney allograft function in the early post-transplant period and to compare this value with that of conventional serum creatinine concentration. Met...

BACKGROUND Since CD44 is involved in activation, proliferation, rolling and extravasation of lymphocytes, we hypothesized that it could be involved in the pathophysiology of acute renal allograft rejection. METHODS Plasma and peripheral blood mononuclear cells (PBMCs) were collected from patients 24 h prior to transplantation and analysed retrospectively. Soluble CD44, interleukin-2 receptor ...

background chronic renal failure is an important and common complication of diabetes mellitus; hence, renal transplantation is a frequent and the acceptable treatment in patients with diabetic nephropathy requiring renal replacement therapy. on the other hand, renal transplantation and its conventional treatment can lead to increased diabetes outbreak in normoglycemic recipients. also, uncontro...

BACKGROUND Chronic renal failure is an important and common complication of diabetes mellitus; hence, renal transplantation is a frequent and the acceptable treatment in patients with diabetic nephropathy requiring renal replacement therapy. On the other hand, renal transplantation and its conventional treatment can lead to increased diabetes outbreak in normoglycemic recipients. Also, uncontro...

BACKGROUND In selected type 1 diabetic (T1DM) patients with end-stage renal disease (ESRD), simultaneous pancreas-kidney transplantation (SPKT) offers higher long-term graft and patient survival, but also higher initial morbidity and mortality than cadaveric kidney transplantation alone (CKTA). The development of new immunosuppressive regimens and surgical approach has improved this initial out...

Purpose: Present and discuss seven cases of allograft nephrectomies performed at our institution for malignancy as the primary indication. Methods: We reviewed retrospectively all patients undergoing allograft nephrectomy at our institution from January 2002 to May 2015. Results: Over a 13 year period, we performed 74 allograft nephrectomies, of which 7 (9.5%) were indicated for malignancy. All...

We report a successful repair of an abdominal aortic aneurysm (AAA) in a renal transplant recipient using a femoral V-A bypass to protect the renal allograft during aortic cross-clamping. A 49-year-old male patient with renal failure had received a second allogenic renal transplantation in the right iliac fossa in 2002. Four years later, computed tomography showed an enlargement of the AAA exte...