نتایج جستجو برای: ipah
تعداد نتایج: 494 فیلتر نتایج به سال:
Idiopathic pulmonary arterial hypertension (PAH [IPAH]) is an insidious and potentially fatal disease linked to a mutation or reduced expression of bone morphogenetic protein receptor 2 (BMPR2). Because intravascular inflammatory cells are recruited in IPAH pathogenesis, we hypothesized that reduced BMPR2 enhances production of the potent chemokine granulocyte macrophage colony-stimulating fact...
In idiopathic portal hypertension (IPH) typical vascular lesions are present in the branches of the portal vein or in the perisinusoidal area of the liver. Similar histological alterations have been reported in the pulmonary vasculature of patients with idiopathic pulmonary artery hypertension (IPAH). As IPAH is associated with mutations of the bone morphogenetic protein receptor 2 (BMPR2) gene...
زمینه و اهداف: شیگلا از عوامل شایع اسهال و مرگ و میر در کودکان زیر 10 سال در کشورهای در حال توسعه شناخته شده است. روشهای روتین ازمایشگاهی برای جداسازی انواع شیگلا وقت گیر و هزینه بر می‌باشد, در این مطالعه به جداسازی زیر گونه‌های شیگلا سونئی از نمونه بیماران مبتلا به دیسانتری بر اساس اهمیت تشخیص ژن تهاجمی و اختصاصی ipaH)) با PCR در مقایسه با روشهای روتین بیوشیمیایی و سرولوژیک پرداخته شده است....
INTRODUCTION In 1981 the “Patient Registry for the Characterization of Primary Pulmonary Hypertension” was set up, supported by the National Heart, Lung and Blood Institute, and recruited 194 patients across 32 clinical centres over 4 years in the United States. The estimated median survival of these incident cases of primary pulmonary hypertension (which approximates to what we would now term ...
he earliest clinical descriptions of primary pulmonary hypertension, now known as idiopathic pulmonary arterial hypertension (IPAH), were accompanied by the hypothesis that pulmonary vasoconstriction was one of its key pathophysiological elements [1] and that vasodilators could, therefore, be therapeutically useful. In support of this concept, DRESDALE et al. [2] first reported attenuation of p...
OBJECTIVE In Japan, there have been no reports on the time-trends of mortality rates from pulmonary heart disease without pulmonary embolism (PHD). Our aim was to examine the annual changes of mortality in Japan. MATERIALS AND METHODS Annual age-adjusted and age-specific PHD mortality for Japanese residents during 1979-2006 were calculated from "Vital statistics of Japan" and census data and ...
Shroom is a PDZ-domain protein involved in the regulation and maintenance of cytoskeletal architecture by binding to actin. Hypertrophy and altered actin organisation of pulmonary arterial smooth muscle cells (PASMC) is a hallmark of pulmonary arterial hypertension (PAH). The aim of the present study was to localise and characterise Shroom expression in the lung in experimental and idiopathic P...
Mutations of the BMPR2 gene predispose to pulmonary arterial hypertension (PAH), a serious, progressive disease of the pulmonary vascular system. However, despite the fact that most PAH families are consistent with linkage to the BMPR2 locus, sequencing only identifies mutations in some 55% of familial cases and between 10% and 40% of cases without a family history (idiopathic or IPAH). We ther...
Flow-directed pulmonary artery occlusion is posited to enable partitioning of vascular resistance into small and large vessels. As such it may have a role in assessment for pulmonary endarterectomy. To test if the occlusion technique distinguished small from large vessel disease we studied 59 subjects with chronic thromboembolic pulmonary hypertension (CTEPH), idiopathic pulmonary arterial hype...
Thyroid disease is known to be associated with pulmonary arterial hypertension (PAH). We investigated the prevalence of thyroid disease in patients with idiopathic PAH (IPAH) or heritable PAH (HPAH), and the factors affecting the pathogenesis of thyroid disease. We retrospectively evaluated 59 patients with IPAH or HPAH who had been diagnosed with PAH before the age of 20 years. Thyrotoxicosis ...
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