BACKGROUND Previous studies in the US and Canada, have shown the positive impact of early palliative care programs for advanced cancer patients on quality of life (QoL) and even survival time. There has been a lack of similar research in Europe. In order to generalize the findings from the US and Canada research on a larger scale, similar studies are needed in different countries with different...

We have used the SHARC II camera at Caltech Submillimeter Observatory to make 350 μm and 450 μm images of the Vega dust disk at spatial resolutions (FWHM) of 9. 7 and 11. 1, respectively. The images show a ring-like morphology (radius ∼ 100 AU) with inhomogeneous structure that is qualitatively different from that previously reported at 850 μm and longer wavelengths. We attribute the 350/450 μm...

Genomic copy number alterations are common in cancer. Finding the genes causally implicated in oncogenesis is challenging because the gain or loss of a chromosomal region may affect a few key driver genes and many passengers. Integrative analyses have opened new vistas for addressing this issue. One approach is to identify genes with frequent copy number alterations and corresponding changes in...

1IPAC Consulting, Woodstock; 2 Institute of Population Health, University of Ottawa, Ottawa, Ontario Correspondence: Mr Norman H Tiffin, IPAC Consulting, 107 Forestway Trail, Woodstock, Ontario N4S 7V6. Telephone 226-376-1414, fax 519-641-4800, e-mail [email protected] Over the past eight years, the registration of clinical trials has been strongly advocated by journals and editors, and is now con...

Activation of the type III secretion apparatus (T3SA) of Shigella flexneri, upon contact of the bacteria with host cells, and its deregulation, as in ipaB mutants, specifically increases transcription of a set of effector-encoding genes controlled by MxiE, an activator of the AraC family, and IpgC, the chaperone of the IpaB and IpaC translocators. Thirteen genes carried by the virulence plasmid...

The intracellular pathogen Shigella flexneri is the causative agent of bacillary dysentery in humans. The disease is characterized by bacterial invasion of intestinal cells, dissemination within the colonic epithelium through direct spread from cell to cell, and massive inflammation of the intestinal mucosa. Here, we review the mechanisms supporting S. flexneri dissemination. The dissemination ...

Detection and photometry of sources in the Un, G, R, and Ks bands in a 9×9 arcmin region of the sky, centered on the Hubble Deep Field, are described. The data permit construction of complete photometric catalogs to roughly Un = 25, G = 26, R = 25.5 and Ks = 20 mag, and significant photometric measurements somewhat fainter. The galaxy number density is 1.3× 10 deg to R = 25.0 mag. Galaxy number...

Distributed applications are increasingly relying on and integrating remote resources including community data sources, services, and computational platforms. The coupling of distributed resources for data-intensive applications can expose bottlenecks across highly shared pathways, e.g. the network. In this paper, we consider applications that access remote clouds for data, computation, or serv...

We present high resolution H I 21 cm line, 20 cm radio continuum, and CO(1–0) line observations of the luminous infrared galaxy NGC 6670. NGC 6670 consists of two edge-on disk galaxies (NGC 6670E and NGC 6670W) with a projected nuclear separation of ∼ 16 kpc. While there are no optically identified tidal features and the molecular disks are not distorted much, we have detected a 90 kpc long H I...

We report the detection of upper main sequence stars and red giant branch stars in the halo of an amorphous galaxy, NGC 3077. The observations were made using Wide Field Planetary Camera 2 on board the Hubble Space Telescope. The red giant branch luminosity function in I-band shows a sudden discontinuity at I = 24.0 ± 0.1 mag. Identifying this with the tip of the red giant branch (TRGB), and ad...