Advanced nasopharyngeal carcinoma (NPC) has a poor prognosis because of the lack of an effective treatment. Here we explored the efficiency and the molecular mechanisms of combined treatment with triptolide and ionizing radiation for treating NPC. Human nasopharyngeal carcinoma (CNE) cells were treated with triptolide, ionizing radiation, or triptolide plus ionizing radiation in vitro. Tumor po...

We calculate the reionization history in Cold Dark Matter (CDM) models. The epoch of the end of reionization and the Thomson scattering optical depth to the cosmic microwave background depend on the power spectrum amplitude on small scales and on the ionizing photon emissivity per unit mass in collapsed halos. We calibrate the emissivity to reproduce the measured ionizing background intensity a...

results the electrophysiology laboratory staff received higher doses of ionizing radiation (17.2 ± 11.9 msv; p < 0.001). there was a significant positive correlation between the years of working experience and effective dose in the lens (p < 0.001). in general, our findings showed that the incidence of lens opacity was 79% (95% ci, 69.9-88.1) in participants with exposure (the case group) and o...

The effect of ionizing radiation on neuronal membrane function was assessed by measurement of neurotoxin-stimulated 22Na+ uptake by rat brain synaptosomes. High-energy electrons and gamma photons were equally effective in reducing the maximal uptake of 22Na+ with no significant change in the affinity of veratridine for its binding site in the channel. Ionizing radiation reduced the veratridine-...

We present an observational test of the spectrum of the ionizing background at z ≃ 5; the test is sufficiently sensitive to determine whether Pop ii or Pop iii stars are the dominant source of ionizing radiation. The ionizing background at z ≃ 5 may reflect the nature of the sources responsible for the final overlap phase of reionization. We find that rest-frame extreme-UV He i absorption will ...

Pregnant women are at risk of exposure to nonionizing and ionizing radiation resulting from necessary medical procedures, workplace exposure, and diagnostic or therapeutic interventions before the pregnancy is known. Nonionizing radiation includes microwave, ultrasound, radio frequency, and electromagnetic waves. In utero exposure to nonionizing radiation is not associated with significant risk...

During the first hour after a sublethal dose of ionizing radiation, 72 genes were upregulated threefold or higher in D. radiodurans R1. Thirty-three of these loci were also among a set of 73 genes expressed in R1 cultures recovering from desiccation. The five transcripts most highly induced in response to each stress are the same and encode proteins of unknown function. The genes (ddrA, ddrB, d...

In oncology, treating cancer with a beam of photons is a well established therapeutic technique, developed over 100 years, and today over 50% of cancer patients will undergo traditional X-ray radiotherapy. However, ionizing radiation therapy is not the only option, as the high-energy photons delivering their cell-killing radiation energy into cancerous tumor can lead to significant damage to he...

OBJECTIVES Although veterinary workers may encounter various occupational health hazards, a national characterization of exposures is lacking in Canada. This study used secondary data sources to identify veterinary exposure prevalence for ionizing radiation and antineoplastic agents, as part of a national surveillance project. METHODS For ionizing radiation, data from the Radiation Protection...