This study demonstrates the use of solid-phase microextraction (SPME) to extract and pre-concentrate volatile signatures from static air above plastic explosive samples followed by detection using ion mobility spectrometry (IMS) optimized to detect the volatile, non-energetic components rather than the energetic materials. Currently, sample collection for detection by commercial IMS analyzers i...

Electrospray ionization–ion mobility spectrometry (ESI-IMS) was used to detect atrazine in a synthetic water sample that contained and water 0.01 M KCl that was collected from a natural cranberry bog. The bog water contained humic substances and had a dissolved organic carbon (DOC) concentration of There 16 mg/l. was no interference from these matrices observed in ESIIMS measurements. The analy...

Ion mobility spectrometer (IMS) has been widely deployed for on-site detection of explosives. The common nitro-based explosives are usually detected by negative IMS while the emerging peroxide-based explosives are better detected by positive IMS. In this study, a fast polarity-switchable IMS was constructed to detect these two explosive species in a single measurement. As the large traditional ...

Matrix-assisted laser desorption/ionisation spiral orbit-type time-of-flight mass spectrometry (MALDI-SpiralTOF) can analyse lipid profiles and characterise lipid structure. Imaging mass spectrometry (IMS) also provides distribution maps of selected m/z values. Here, we investigated triacylglycerol (TG) structure and distribution using these technologies to estimate mouse fatty liver. The distr...

The binding properties of a peptidoglycan recognition protein are translated via combinatorial chemistry into short peptides. Non-adjacent histidine, tyrosine, and arginine residues in the protein's binding cleft that associate specifically with the glycan moiety of a peptidoglycan substrate are incorporated into linear sequences creating a library of 27 candidate tripeptide reagents (three pos...

The use of ion mobility separations (IMSs) in metabolomics approaches has started to be deeply explored the last years. In this work, liquid chromatography (LC) coupled IMS-quadrupole time-of-flight mass spectrometry (QTOF MS) been evaluated a experiments using single injection samples. IMS allowed obtaining cleaner fragmentation spectra, nearly tandem MS quality, data-independent acquisition m...