INTRODUCTION Of all forms of stroke, spontaneous intracerebral haemorrhage (ICH) causes the highest morbidity and mortality. The Surgical Trial in Intracerebral Haemorrhage (STICH) found no difference in outcomes between patients randomized to surgical or conservative treatment. PATIENTS AND METHODS Of 530 patients randomized to initial conservative treatment, 140 crossed over to surgery. Thi...

In a population based register of stroke (n = 536) compiled in Perth, Western Australia during an 18 month period in 1989-90, 60 cases (11%) of primary intracerebral haemorrhage were identified among 56 persons (52% men). The mean age of these patients was 68 (range 23-93) and 46 (77%) events were first ever strokes. The crude annual incidence was 35 per 100,000, with a peak in the eighth decad...

AIMS To examine the effectiveness of prophylactic intravenous indomethacin in reducing the mortality and morbidity associated with patent ductus arteriosus and intraventricular haemorrhage in infants weighing less than 1750 g at birth. METHODS A literature search from 1980 onwards was made of three databases: Medline; Embase; and the Oxford Database of Perinatal Trials. Using strict criteria ...

BACKGROUND Rates of long term morbidity remain unacceptably high in infants surviving after preterm birth. Prophylactic indomethacin has been shown to effectively reduce the rate of intraventricular haemorrhage in this group but there is the potential for unwanted side effects because of reduced organ perfusion. OBJECTIVE To examine the effect of prophylactic indomethacin on mortality and sho...

BACKGROUND The incidence of preterm meconium staining of the amniotic fluid (MSAF) is uncertain. It may be an indicator of possible listeriosis. It is unclear how great this risk is or whether preterm MSAF is a risk factor for adverse neonatal outcome. OBJECTIVE To investigate the incidence of preterm MSAF, the incidence of associated maternal and neonatal infection, and the outcomes of the i...

BACKGROUND Optimal timing for clamping of the umbilical cord at birth is unclear. Early clamping allows for immediate resuscitation of the newborn. Delaying clamping may facilitate transfusion of blood between the placenta and the baby. OBJECTIVES To delineate the short- and long-term effects for infants born at less than 37 completed weeks' gestation, and their mothers, of early compared to ...

Abstract Background Spontaneous intraventricular haemorrhage (IVH) is a life-threatening condition associated with high morbidity and mortality conventionally managed using external ventricular drain (EVD). However, EVD commonly rate of complications, which necessitates another alternative management comparable or better outcome. This study aims to compare the efficacy safety ventriculosubgalea...