In dogs with myocardial infarction, produced by a standard technic, rapid persistent ectopic ventricular tachycardia develops. Intravenous quinidine lactate and quinidine gluconate effectively control the arrhythmia in 56 to 60 per cent of the animals, but produce toxic reactions in many of them. Morphine sulfate prevents vomiting and diarrhea from quinidine, but does not prevent convulsive mov...

Postoperative management of pain has traditionally utilized intravenous (IV) morphine for pain control. An alternative approach to the invasive patient-controlled analgesia (PCA) system is the administration of transdermal analgesics, such as fentanyl. In 2006 the Food and Drug Administration (FDA) approved the fentanyl hydrochloride (fentanyl HCl) iontophoretic transdermal system (ITS), which ...

BACKGROUND The analgesic efficacy and side effect profile of intravenous parecoxib, a novel cyclooxygenase type-2 (COX-2) inhibitor, was assessed in a double-blinded, placebo-controlled study involving patients undergoing major gynecologic surgical procedures. METHODS After Institutional Review Board approval, 60 consenting women, American Society of Anesthesiologists (ASA) physical status I-...

OBJECTIVE To determine whether pre- and post-operative administration of intravenous ibuprofen (IV-ibuprofen) can significantly decrease pain and morphine use when compared with placebo in adult orthopedic surgical patients. DESIGN This was a multi-center, randomized, double-blind placebo-controlled trial. SETTING This study was completed at eight hospitals; six in the United States and two...

OBJECTIVE To compare the effectiveness of intravenous (IV) morphine, intranasal (IN) fentanyl, and inhaled methoxyflurane when administered by paramedics to patients with moderate to severe pain. METHODS We conducted a retrospective comparative study of adult patients with moderate to severe pain treated by paramedics from the Ambulance Service of New South Wales who received IV morphine, IN ...

BACKGROUND A systematic review and meta-analysis of published randomized controlled trials (RCTs) were performed to assess the efficacy and safety of preoperative intravenous glucocorticoids versus controls for the prevention of postoperative acute pain and postoperative nausea and vomiting (PONV) after primary total hip arthroplasty (THA). METHODS A computer literature search of electronic d...