1. Kumar A, Teuber SS, Gershwin ME. Intravenous immunoglobulin: striving for appropriate use. Int Arch Allergy Immunol. 2006:140:185-98. 2. Fergusson D, Hutton B, Sharma M, Tinmouth A, Wilson K, Cameron DW, Hebert PC. Use of intravenous immunoglobulin for treatment of neurologic conditions: a systematic review. Transfusion (Paris). 2005:45:1640-57. 3. Dalakas MC. Intravenous immune globulin the...

introduction: acute idiopathic thrombocytopenic purpura (itp) is an autoimmune bleeding disorder of childhood caused by production of auto antibodies against platelets. the aim of the present study was to compare the efficacy of intravenous immunoglobulin (ivig) and intravenous anti-d(iv anti-d) in itp treatment. methods and materials: in a clinical trial, 43 children with acute itp referred to...

Rheumatoid arthritis is a chronic inflammatory disease that results in progressive disability and increased mortality. New therapeutic strategies are being recommended to initiate, earlier than in the past, more aggressive use of disease-modifying drugs in an effort to reduce joint destruction. In this article, the results of recent clinical trials with nonsteroidal anti-inflammatory drugs, int...

Transdermal delivery is preferable for some drugs to oral administration or intravenous injection. Macromolecules such as peptide drugs, however, little penetrate through the skin. Iontophoresis is an effective transdermal method for macromolecules. In this study the effect of duration of applying electric field and degree of current density has been investigated under in vitro conditions. The ...

Effects of antiarrhythmic drugs upon the threshold delivered energy (TDE) and threshold peak current (TPC) for electrical ventricular defibrillation by damped sinusoidal shocks were investigated in 25 pentobarbital-anesthetized dogs. TDE and TPC were increased by the three antiarrhytmic drugs tested. Bolus injections produced a transient rise and continuous infusions produced a steady rise in d...

In the review paper an issue of the administration of iron containing drugs in the treatment of anemia in non-dialyzed patients with chronic kidney disease (CKD) is presented. Iron deficiency in patients with CKD (serum ferritin concentration below 100 ng/ml, transferrin saturation below 20%) occurs in 20-70% of cases. Prevalence of iron deficiency depends on stage of CKD and patients' gender. ...

BACKGROUND Non-steroidal anti-inflammatory drugs are considered today a very important group of medication, with a wide variety of therapeutic use, in different areas of modern medicine. Despite their beneficial effects on the patient, these drugs show a high incidence of side effects, mainly in the gastrointestinal tract. The physiopathological mechanisms of non-steroidal anti-inflammatory dru...

BACKGROUND Treatment of sudden sensorineural hearing loss (SSNHL) consists of administration of blood flow-promoting drugs with or without the addition of glucocorticoids. General guidelines based on scientific data do not currently exist. OBJECTIVE To investigate the effect of glucocorticoids on the treatment of SSNHL. SETTING Academic medical center. PATIENTS AND METHODS We retrospectiv...