In view of the relatively few communications on pneumonia in children following the aspiration of oil or fat, it seems desirable to report twot cases of this kind which were observed on the Pediatric Service of the New Haven Hospital. Pinkerton"'2 reviewed the literature on this subject and reported six cases from the Children's Hospital in Boston. All of these patients died of pneumonia follow...

Monkeys and dogs were used in a series of studies designed to assess the ability of aurin tricarboxylic acid (ATA) to provide protection against acute beryllium poisoning. The acute LD50 of ATA was found to be 344 mgA/g for monkeys and 164 mg/kg for dogs. Neither species exhibited significant hematological changes when given weekly ATA doses of 25 mg/kg over an 8-month period. The lethal intrav...

A methodology for the experimental induction of bronchogenie carcinoma in conditions related to those of human expo sure to respiratory carcinogens is described. Animal of choice is the hamster. Polynuclear hydrocarbon carcinogens are pre pared as suspensions of fine crystalline particles and attached to a finely particulated inert dust which acts as a carrier; the mixed dust is suspended in sa...

It has been possible to sensitize guinea pigs by the intratracheal administration of small amounts of horse or cow serum. The degree of sensitiveness is comparable to that obtained when the same doses of serum are injected into the peritoneal cavity. Nevertheless, relatively small amounts of foreign protein are slowly absorbed through the lining membranes of the lower respiratory tract. In sens...

Exposure to air pollution is associated with increased cardiovascular risk but the mechanisms are poorly understood. The aim of this investigation was to assess the effect, in rats, of intratracheal instillation of particulate air pollution on leucocyte activation and damage to the vascular endothelium. Rats were exposed to particulate air pollution by intratracheal instillation of PM10. Blood ...