نتایج جستجو برای: intramolecular michael addition

تعداد نتایج: 747019  

2017
Sunyoung Choi Sung-Gon Kim

Ethyl 2-[2-(4-nitrobenzoyl)-1H-indol-3-yl]acetate was prepared in good yield and characterized by the aza-alkylation/intramolecular Michael cascade reaction of (E)-ethyl 3-[2-(tosylamino)phenyl]acrylate with 2-bromo-4′ ′-nitroacetophenone, followed by desulfonative dehydrogenation with 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) The structure of the newly synthesized compound was determined using ...

Journal: :Organic & biomolecular chemistry 2016
M Palomba L Rossi L Sancineto E Tramontano A Corona L Bagnoli C Santi C Pannecouque O Tabarrini F Marini

Herein, we disclose a general and flexible access to spirocyclopropyl oxindoles by a domino Michael/intramolecular nucleophilic substitution pathway with variously substituted vinyl selenones and enolizable oxindoles in aqueous sodium hydroxide solution. The spirocyclopropyl oxindole being a privileged scaffold, some of the synthesized compounds were selected for biological evaluation. Compound...

Journal: :Organic letters 2013
Xavier Elduque Enrique Pedroso Anna Grandas

Cyclic peptide architectures can be easily synthesized from cysteine-containing peptides with appending maleimides, free or protected, through an intramolecular Michael-type reaction. After peptide assembly, the peptide can cyclize either during the trifluoroacetic acid treatment, if the maleimide is not protected, or upon deprotection of the maleimide. The combination of free and protected mal...

Journal: :Chemical communications 2012
Maitane Fernández Jose L Vicario Efraím Reyes Luisa Carrillo Dolores Badía

We have developed an efficient procedure for the easy and straightforward preparation of functionalized dihydropyridazines as highly enantiopure materials by reaction of pyruvaldehyde 2-tosyl hydrazone with a variety of α,β-unsaturated aldehydes using a chiral secondary amine as catalyst. The overall process consists of a cascade reaction involving an initial aza-Michael reaction, in which the ...

Journal: :Organic & biomolecular chemistry 2010
Miriam Ruiz Pilar López-Alvarado J Carlos Menéndez

An efficient synthesis of the N-methylwelwistatin tetracyclic core in only two steps from Kornfeld's ketone is described, whose key transformation involves the generation of a fused bicyclo[4.3.1]decane ring system through a one-pot sequence comprising a Michael-intramolecular aldolization anionic domino process and a DBU-promoted hydrolysis of the N-pivaloyl protecting group. Besides providing...

Journal: :Tetrahedron 2009
Dinesh Kumar Rayabarapu Aihua Zhou Kyu Ok Jeon Thiwanka Samarakoon Alan Rolfe Hina Siddiqui Paul R Hanson

The development of new methods to skeletally diverse sultams based on a central α-halo benzene sulfonamide building block is reported. Several salient features of this building block are utilized in multiple reaction pathways, including the Heck reaction, C- and O-arylation, Sonogashira-Pauson-Khand, Sonogashira-intramolecular hydroamination, lithiative cyclization and domino aza-Michael Heck f...

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