STUDY DESIGN A biomechanical study using human spine specimens. OBJECTIVE The aim of this study was to assess whether the presence of cervical sagittal imbalance is an independent risk factor for increasing the mechanical burden on discs adjacent to cervical multilevel fusions. SUMMARY OF BACKGROUND DATA The horizontal offset distance between the C2 plumbline and C7 vertebral body (C2-C7 Sa...

BACKGROUND The purpose of this biomechanical in vitro study was to compare the kinematics and intradiscal pressure achieved with 2 methods: L4-L5 pedicle screw-rod fixation (PSRF) with an upper L3-L4 Coflex device and L4-L5 PSRF alone. The results were used to characterize the biomechanics of the topping-off operation with a Coflex device for the lumbar motion segment adjacent to single-level r...

Target of the study was to predict the biomechanics of the instrumented and adjacent levels due to the insertion of the DIAM spinal stabilization system (Medtronic Ltd). For this purpose, a 3-dimensional finite element model of the intact L3/S1 segment was developed and subjected to different loading conditions (flexion, extension, lateral bending, axial rotation). The model was then instrument...

BACKGROUND CONTEXT Biochemical treatment options including attempts at intervertebral disc restoration are desirable for the physiologic treatment of degenerative disc disease. PURPOSE This was a pilot study to test the potential effectiveness of intradiscal injection therapy using agents known to induce proteoglycan synthesis in the treatment of intervertebral disc disease. STUDY DESIGN Pr...

This article focuses on the estimation of population proportion when the study variable is sensitive in nature. Two implicit randomized response techniques are proposed where the unrelated trait can be chosen subjectively. In addition to unbiased estimation of population proportion and variance, an empirical study is conducted to inspect the relative efficiency facet of the proposed techniques....

Surgery is the treatment of choice for symptomatic disc herniation after conservative management. Several studies have suggested potential utility intradiscal ozone infiltration in this pathology. The aim trial was to compare vs. oxygen surgery. This a randomized, double-blinded, and controlled patients on waiting list herniated There were three groups: surgery; (plus foraminal ozone, steroids,...

BACKGROUND Although numerous animal models for low back pain associated with intervertebral disk (IVD) degeneration have been proposed, insufficient data have been provided to make any conclusions regarding pain. Our aim in this study was to determine the reliability of complete Freund's adjuvant (CFA) injection into the rat spine as an animal model representing human discogenic pain. METHODS...