Objective: Pontocerebellar angle (PCA) tumors, although typically of benign nature, are significant clinical and pathological importance. The aim this study is to investigate the characteristics PCA as well surgical outcomes, which hold a place in practice. Methods: 55 adult patients who underwent surgery for tumors at Department Neurosurgery, Dicle University Faculty Medicine, between 2013 202...

Intraventricular meningiomas account for 9.8-14% of all intraventricular tumors and for 20% of lateral ventricle tumors [1,2]. Meningiomas of the lateral ventricle constitute 0.5-4.5% of all intracranial meningiomas [3,4]. Between 60% and 94% of them arise from the choroid plexus at the trigone. The predilection for the trigone may be attributed to the abundance of choroid plexus arachnoidea. T...

BACKGROUND Congenital intracranial tumors as a group are quite rare, representing only 0.5% to 1.5% of all pediatric brain neoplasms. CASE REPORT We reported a case of congenital mixed neuronal-glial tumor detected by ultrasound at 30 weeks of gestation. It showed that the tumor was 2.5 × 2.3 × 2.1 cm in size, located in the sellar region, regular shape, and slightly heterogeneous solid mass ...

BACKGROUND AND PURPOSE MR imaging has made it easier to distinguish among the different types of intracranial mass lesions. Nevertheless, it is sometimes impossible to base a diagnosis solely on clinical and neuroradiologic findings, and, in these cases, biopsy must be performed. The purpose of this study was to evaluate the hypothesis that proton MR spectroscopy is able to improve preoperative...

Glioblastoma multiforme (GBM) is a common, usually lethal disease with a median survival of only ~15 months. It has proven resistant in clinical trials to chemotherapeutic agents such as paclitaxel that are highly effective in vitro, presumably because of impaired drug delivery across the tumor's blood-brain barrier (BBB). In an effort to increase paclitaxel delivery across the tumor BBB, we li...

BACKGROUND AND OBJECTIVE Primary intracranial germ cell tumors (GCTs) are a class of heterogeneous tumors. Surgery can quickly relieve tumor compression and provide histological diagnosis. It is very difficult to treat some patients who are unable to be pathologically diagnosed. We aimed to analyze clinically diagnosed GCTs patients. METHODS Patients clinically diagnosed as primary intracrani...

Due to lack of effective therapy, primary brain tumors are the focus of intense investigation of novel experimental approaches that use vectors and recombinant viruses. Therapeutic approaches have been both indirect, whereby vectors are used, or direct to allow for direct cell killing by the introduced virus. Genetically engineered herpes simplex viruses are currently being evaluated as an expe...

BACKGROUND Brain tumors are the second most common malignancy in childhood and they are also the most common solid tumors in children and the most frequent cause of morbidity and mortality associated with cancer in this age. OBJECTIVE To determine the clinical presentation of supratentorial and infratentorial intracranial tumors in pediatric patients. MATERIAL AND METHODS An observational, ...

Most IDH mutant gliomas harbor either 1p/19q co-deletions or TP53 mutation; 1p/19q co-deleted tumors have significantly better prognoses than tumors harboring TP53 mutations. To investigate the clinical factors that contribute to differences in tumor progression of IDH mutant gliomas, we classified recurrent tumor patterns based on MRI and correlated these patterns with their genomic characteri...

Most meningiomas are benign; however anaplastic usually highly invasive and grow rapidly. These tumors can metastases outside the blood-brain barrier occurring to lungs. We present an unusual case of multiple pulmonary from recurrent intracranial meningioma in a 59-year-old male patient. Multiple very rare, but we should be aware this possibility patients with malignant especially, potential pr...