The objective of the current study is to develop a validated, specific and stability-indicating reverse phase liquid chromatographic method for the quantitative determination of genotoxic impurities in the drug substance imatinib mesylate. This report includes a brief review of the toxicology of impurities in imatinib mesylate and the strategies used to set acceptance criteria for genotoxic imp...

A rapid, precise, sensitive, economical, and validated high performance thin layer chromatographic method is developed for simultaneous quantification of olmesartan medoxomil and hydrochlorothiazide in combined tablet dosage form. The method used amlodipine as internal standard (IS). Chromatographic separations were achieved on silica gel 60 F254 plates using toluene-methanol-ethyl acetate-acet...

portant part of the drug development process, and the pharmaceutical industry’s considerable interest in this topic has led to the publication of an article by the Pharmaceutical Research and Manufacturer’s of America (PhRMA) in Pharmaceutical Technology (1). Although the concept of stress testing is not new to the pharmaceutical industry, the procedure was not clearly defined until the Interna...

Contents 1 Introduction 2 2 Forms of internationalization in higher education 4 2.1 Student mobility 4 2.2 Teaching staff mobility 6 2.3 Internationalization of curricula 7 2.4 Branch campuses 9 2.5 Institutional cooperation agreements and networks 9 2.6 Mutual recognition agreements 9 2.7 Transnational university networks (incl. mergers of institutions) 10 2.8 Transnational virtual delivery of...

In February 2006, the Chinese Ministry of Finance formally announced that, from 2007 onwards, the Chinese Accounting Standards (CAS) would be converging with International Accounting Standards (IAS). This significant step towards international accounting harmonization, for the purpose of attracting foreign investment, invokes the question as to whether the newly implemented IAS will indeed achi...

In view of the ever-increasing globalisation of economy, the removal of technical barriers to trade has become a central political task. To establish the preconditions for free trade throughout world, the World Trade Organization adopted agreement encouraging the development of mutual recognition agreements and of international conformity assessment systems. Such agreements are based on mutual ...

Mercenary activities in wars and other armed conflicts, as a social phenomenon, do not stop intriguing both moral, legal financial terms, from the first conflicts until today. Although present practically throughout entire human history, regulation of mercenary aspect international law well national legislation was completely neglected recently. It only after World War II that documents were cr...

In this article, we explore regulatory developments in stem cell medicine in seven jurisdictions: Japan, China, India, Argentina, Brazil, the USA and the EU. We will show that the research methods, ethical standards and approval procedures for the market use of clinical stem cell interventions are undergoing an important process of global diversification. We will discuss the implications of thi...