Many cellular functions involve the complex network of actin filaments, microtubules, and intermediate filaments collectively known as the cytoskeleton. Stereo transmission electron microscopic observations of whole cynomolgus monkey trabecular cells, which were extracted, S-1 labeled, and critical-point dried, were employed to simultaneously identify these three major cytoskeletal systems and ...

Background: Hydroxyurea (HU) is a well known chemotherapeutic agent that has been used largely for various myeloproliferative diseases over the past 20 years. In β-thalassemia, the effect of HU is much less clear and remains controversial. This study was undertaken to describe the hematologic and clinical responses of thalassemia major and intermediate patients to HU treatment during 2 years. M...

results of the bromination and dehydrobromination of several angular methylated decalindiones are described. the key reaction, base-induced cyclization of the monobromo keto ester (3), and the dibromo ketone (4), leads to the formation of tricyclic systems (6) and (9) respectively.

this study was an attempt to investigate whether teaching critical reading strategies had any significant effect on intermediate efl learners’ vocabulary retention. to fulfill the purpose of this study, 72 male and female students within the age range of 17 to 32 years studying at farzan and farzanegan language schools in tehran at intermediate level were selected from a total number of 114 par...

The Espress project aims at a method for the development of safety-critical embedded technical systems which bases on strong mathematical concepts. To make such a method competetive with other approaches nowadays common in industrial practise it must be ultimatively supported by an elaborated set of tools integrated in a software development environment (SDE). Since the Espress project is not c...

The semiflexible polymers filamentous actin (F-actin) and intermediate filaments (IF) both form complex networks within the cell, and together are key determinants of cellular stiffness. While the mechanics of F-actin networks together with stiff microtubules have been characterized, the interplay between F-actin and IF networks is largely unknown, necessitating the study of composite networks ...

Runtime security policy enforcement systems are crucial to limit the risks associated with running untrustworthy (malicious or buggy) code. The inlined reference monitor approach to policy enforcement, pioneered by Erlingsson and Schneider, implements runtime enforcement through program rewriting: security checks are inserted inside untrusted programs. Ensuring complete mediation – the guarante...

The properties of full-length and mutant peripherins were studied in intermediate filament-less SW13 cells to define regions of peripherin that are essential for initiation of filament assembly. A full-length rat peripherin gene transfected into SW13 cells resulted in filament formation, consistent with the close structural relationship of peripherin to other type III intermediate filament prot...

Type IV neuronal intermediate filament proteins consist of alpha-internexin, which can self-assemble into filaments and the neurofilament triplet proteins, which are obligate heteropolymers, at least in rodents. These IF proteins therefore provide good systems for elucidating the mechanism of intermediate filament assembly. To analyze the roles of the head domains of these proteins in contribut...