The vast majority of Foxp3 regulatory T cells (Treg) exhibits constitutive expression of CD25 (IL-2Rα), which allows the constitution of the high affinity IL-2Rαβγ receptor, ensuring efficient IL-2 binding by Treg. Maintenance of CD25 expression at Treg surface depends on both cell intrinsic factors and environmental stimuli such as IL-2 itself. Whether other factors can participate to maintena...

Both antigen-presenting cells and immune effector cells are required to effectively eradicate or contain Mycobacterium tuberculosis-infected cells. A variety of cytokines are involved to ensure productive "cross talk" between macrophages and T lymphocytes. For instance, infection of macrophages with mycobacteria leads to effective interleukin-7 (IL-7) and IL-15 secretion, and both cytokines are...

Interleukin 7 is a crucial factor for the development of murine T and B lymphocytes. We now report that, in the absence of interleukin 7, B lymphocyte production takes place exclusively during fetal and perinatal life, ceasing after 7 wk of age. In peripheral organs, however, the pool of B lymphocytes is stable throughout adult life and consists only of cells that belong to the B1 and marginal ...

3. Xu Y, Carr LG, Bosron WF, Li T-K, Edenberg HJ. Genotyping of human alcohol dehydrogenases at the ADH2 and ADH3 loci following DNA sequence amplification. Genomics. 1988;2:209-214. 4. Aoshima T, Umetsu K, Yuasa I, Watanabe G, Suzuki T. Simultaneous genotyping of alcohol dehydrogenase 2 (ADH2) and aldehyde dehydrogenase 2 (ALDH2) loci by amplified product length polymorphism (APLP) analysis. E...

As an attempt to prevent transition-period-associated metabolic disorders and/or diseases, the potential benefits of Boswellia sacra (Bs) resin on hematology, immunity, status, udder and uterus health biomarkers, milk production were examined in transitioning goats. From 2 weeks prepartum 7 postpartum, goats (n = 7/treatment) orally received 0 (control, nBS), (BsL), or 4 (BsH) g Bs resin/goat/d...

based on the evidence regarding the relationship between inflammatory processes and stress responses, the present study investigated the association between psychological stress and elevation of inflammatory mediators related to periodontal disease in adult patients.the study consisted of 50 patients including 25 patients with chronic periodontitis and 25 cases with aggressive periodontitis. tw...

background: the purpose of the present study was to compare the serum levels of il6 and ca125 in women with and without endometriosis. they were also compared in mild, moderate and severe cases. methods: in this case-control study, ca125 and il6 levels in 76 women with laparoscopic proven endometriosis were compared with 76 women without evidence of endometriosis. sensitivity, specificity, posi...