Human oral squamous carcinoma is considered the most common cancer; it imposes multiple and dental consequences as a result of cancer treatment. We previously found that nanoencapsulation cordycepin (CS) could inhibit cells. However, mechanism action was not understood. The aim this study to investigate signaling pathway by which CS encapsulated nanoparticles (NPs) activate inhibition cell grow...

1. Abstract 2. Introduction 2.1. HPV infection and carcinogenesis 2.2. Major transforming activities 2.3. The HPV life cycle 3. Section 3. The HPV E7 protein 3.1. Cellular targets of HPV E7 proteins: the retinoblastoma protein family 3.2. Cellular targets of HPV E7 proteins: cyclin-dependent kinase inhibitors 3.3. Cellular targets of HPV E7 proteins: chromatin modifying factors 4. Section 4. Th...

background: it has been reported that secreted frizzled-related protein-4 known as an antagonist of wnt signaling pathway plays a role in luteinization process of rodent granulosa cells. the purpose of this study was twofold: 1) to determine whether recombinant human secreted frizzled-related protein-4 (rhsfrp-4) could directly induce terminal differentiation of rat granulosa cells (gcs) and 2)...

background: a dinucleotide variant rs368234815 in interferon lambda 4 (ifnl4) gene was recently found to be associated with the hepatitis c virus (hcv) treatment response. this study aimed to assess the impact of ifnl4 rs368234815 polymorphism on treatment response to pegylated?ifn alpha (peg?ifn??) and ribavirin (rbv) in hemophilic patients with chronic hepatitis c (chc). materials and methods...