نتایج جستجو برای: integrins

تعداد نتایج: 15451  

Journal: :Development 2004
Thomas Pietri Olivier Eder Marie Anne Breau Piotr Topilko Martine Blanche Cord Brakebusch Reinhard Fässler Jean-Paul Thiery Sylvie Dufour

Integrins are transmembrane receptors that are known to interact with the extracellular matrix and to be required for migration, proliferation, differentiation and apoptosis. We have generated mice with a neural crest cell-specific deletion of the beta1-integrin gene to analyse the role of beta1-integrins in neural crest cell migration and differentiation. This targeted mutation caused death wi...

2013
Tobias Petzold Raphael Ruppert Dharmendra Pandey Verena Barocke Hannelore Meyer Michael Lorenz Lin Zhang Wolfgang Siess Steffen Massberg Markus Moser

The rupture of atherosclerotic plaques leads to the exposure of matrix proteins, which in turn trigger arterial thrombosis, leading to stroke and cardiac infarction. Different platelet receptors sense the exposed matrix and induce platelet activation and secretion of prothrombotic molecules, leading to further platelet recruitment and finally thrombus formation. Integrins represent the major fa...

Journal: :Investigative ophthalmology & visual science 1993
S K Masur J K Cheung S Antohi

PURPOSE The integrins are a family of transmembrane glycoproteins that function in attachment of cells to one another and to the extracellular matrix. When cell--cell and cell--matrix interactions are altered, the population of integrins may change. In particular, removing cells from their normal environment may be used as a model of wounding. The current study reports the identification of the...

2005
Daniela Taverna Denise Crowley Mary Connolly Roderick T. Bronson Richard O. Hynes

AvB3 or AvB5 integrins are widely expressed on blood and endothelial cells. Inhibition of the functions of these integrins has been reported to suppress neovascularization and tumor growth, suggesting that they may be critical modulators of angiogenesis. However, mice lacking these integrins exhibit extensive angiogenesis. Tumors arising from s.c. injections of tumor cells into mice lacking one...

Journal: :Journal of cell science 1998
D Dogic P Rousselle M Aumailley

Laminin 1 (alpha1beta1gamma1) and laminin 5 (alpha3beta3gamma2) induce cell adhesion with different involvement of integrins: both are ligands for the alpha6beta1 integrin, while alpha3beta1 integrin has affinity for laminin 5 only. These two laminin isoforms therefore provide good models to investigate whether alpha3beta1 and alpha6beta1 integrins play different roles in signal transduction an...

Journal: :Journal of cell science 2012
Mohamed Bouaouina Klodiana Jani Jenny Y Long Stefan Czerniecki Elizabeth M Morse Stephanie J Ellis Guy Tanentzapf Frieder Schöck David A Calderwood

Integrins are heterodimeric adhesion receptors that link the extracellular matrix (ECM) to the cytoskeleton. Binding of the scaffold protein, talin, to the cytoplasmic tail of β-integrin causes a conformational change of the extracellular domains of the integrin heterodimer, thus allowing high-affinity binding of ECM ligands. This essential process is called integrin activation. Here we report ...

Journal: :Cell 1996
Kishore K Wary Fabrizio Mainiero Steven J Isakoff Eugene E Marcantonio Filippo G Giancotti

We provide evidence that a class of integrins combines with the adaptor Shc and thereby with Grb2. Coimmunoprecipitation and mutagenesis experiments indicate that the recruitment of Shc is specified by the extracellular or transmembrane domain of integrin alpha subunit and suggest that this process is mediated by caveolin. Mutagenesis and dominant-negative inhibition studies reveal that Shc is ...

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