نتایج جستجو برای: insulitis

تعداد نتایج: 749  

Journal: :Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion 2009
Massimo Trucco

Type 1 diabetes (T1D) mellitus can best be characterized as a disorder of gluco-regulation due to the insufficient production of a single critical hormone: insulin. Since the middle of the last century the most efficient pharmacologic solution has been to administer the hormone to the patient daily. Increasingly sophisticated dosing schedules together with the availability of recombinant varian...

Journal: :International journal of experimental diabetes research 2000
S. Reddy M. Karanam E. Robinson

Spontaneous diabetes in the NOD mouse can be prevented by nicotinamide or by an infant formula diet in which the protein source is replaced with casein hydrolysate (Pregestimil) or soy protein (Prosobee). NOD mice maintained on the standard diet (chow and water) and given cyclophosphamide (Cy) at day 95 develop accelerated and synchronised diabetes within 14 days. Here, we compared the ability ...

2014
Dorothy N. Kakoola Anita Curcio-Brint Nataliya I. Lenchik Ivan C. Gerling

Type 1 diabetes (T1D) is a multigenic disease caused by T-cell mediated destruction of the insulin producing pancreatic islet ß-cells. The earliest sign of islet autoimmunity in NOD mice, islet leukocytic infiltration or insulitis, is obvious at around 5 weeks of age. The molecular alterations that occur in T cells prior to insulitis and that may contribute to T1D development are poorly underst...

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