نتایج جستجو برای: inha inhibition
تعداد نتایج: 328589 فیلتر نتایج به سال:
Dae-Hyun Kim, Sang-Bae Ko, Jae-Kwan Cha, Keun-Sik Hong, Kyung-Ho Yu, Ji Hoe Heo, Sun-Uck Kwon, Hee-Joon Bae, Byung-Chul Lee, Byung-Woo Yoon, Jeong Eun Kim, Hyun-Seung Kang, Dae-Hee Seo, Sukh-Que Park, Seung Hun Sheen, Hyun Sun Park, Sung Don Kang, Jae Min Kim, Chang Wan Oh, In Sung Park, Joung-Ho Rha Department of Neurology, Dong-A University College of Medicine, Busan, Korea Department of Neur...
The aim of the present study was to evaluate inhibin secretion in rats with autoimmune orchitis. As we have previously described, experimental autoimmune orchitis (EAO) induced in rats by active immunization with testis homogenate and adjuvants is characterized by an interstitial mononuclear cell infiltrate and sloughing of the germinal epithelium. At 120 days after the first immunization 60% o...
Introduction Mycobacterium tuberculosis (MTB), the causative agent of tuberculosis, has been a global threat to human beings for several decades. Treating become more difficult as prevalence drug-resistant increased globally. Evidence suggests that comprehensive landscape resistance mechanisms in MTB is ambiguous. More importantly, little known regarding series events connected before exposure ...
A series of novel bis 1,2,3-triazole derivatives 2-Hydroxyquinoline-4-carboxylate, exhibiting diverse molecular structures were synthesized through a click reaction, incorporating combination moieties and quinoline nucleus. In vitro biological studies conducted to evaluate their antitubercular, antibacterial antifungal activities. To explore the behavioural selective properties molecules, exper...
Despite the fact that Nepal is one of the first countries globally to introduce multidrug-resistant tuberculosis (MDR-TB) case management, the number of MDR-TB cases is continuing to rise in Nepal. Rapid molecular tests applicable in this setting to identify resistant organisms would be an effective tool in reversing this trend. To develop such tools, information about the frequency and distrib...
A total of 105 rifampin (RMP)- and/or isoniazid (INH)-resistant strains of Mycobacterium tuberculosis isolated from different parts of Poland in 2000 were screened for mutations associated with resistance to these drugs by two molecular methods, namely sequence analysis and real-time PCR technology. Three loci associated with drug resistance were selected for characterization: they were rpoB (R...
Developing a fast, inexpensive, and specific test that reflects the mutations present in Mycobacterium tuberculosis isolates according to geographic region is the main challenge for drug-resistant tuberculosis (TB) control. The objective of this study was to develop a molecular platform to make a rapid diagnosis of multidrug-resistant (MDR) and extensively drug-resistant TB based on single nucl...
Mycobacterium phenotypic hits are a good reservoir for new chemotypes for the treatment of tuberculosis. However, the absence of defined molecular targets and modes of action could lead to failure in drug development. Therefore, a combination of ligand-based and structure-based chemogenomic approaches followed by biophysical and biochemical validation have been used to identify targets for Myco...
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