Preliminary data have suggested that children milder COVID-19 disease course compared to adults. However, pediatric cases with severe clinical findings caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) are being reported since April 2020. These been presented significant hyperinflammatory states resembling Kawasaki disease, toxic shock syndrome, and macrophage activation sy...

PURPOSE The role of systemic inflammation on asthma-COPD overlap syndrome is unknown. This study aimed to examine systemic inflammation in asthma-COPD overlap syndrome, and to identify associations between clinical characteristics and inflammatory mediators in asthma-COPD overlap syndrome. METHODS In 108 adults older than 55 years comprising healthy controls (n=29), asthma (n=16), COPD (n=21)...

OBJECTIVE Individuals with metabolic syndrome have increased risk of type 2 diabetes and cardiovascular disease. We aimed to test the hypothesis that a high level of cardiorespiratory fitness (CR-fitness), counteracts accumulation of visceral fat, decreases inflammation and lowers risk factors of the metabolic syndrome. METHOD The study sample included 1,293 Danes (age 49-52 years) who from 2...

the concepts of SIRS and CARS still exist, although the notion that CARS represents a reaction to SIRS has been challenged [3, 4] . In this theme issue of the Journal of Innate Immunity, current knowledge of several aspects of the SIRS and CARS concepts are reviewed in 7 articles; the issue is completed by 3 original articles about these topics. Kumpf and Schumann [5] summarize data on genetic ...

Endothelial dysfunction plays a crucial role in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection and has recently been proposed to be connected with thrombosis, hyper-inflammation, cytokine storm syndrome, immune cell recruitment, platelet aggregation, vasoconstriction endothelial apoptosis. Importantly, certain mediators pro-inflammatory cytokines such as galectin (Gal) 1...