INTRODUCTION In a recent screening to detect biomarkers in systemic lupus erythematosus (SLE), expression of the iron storage protein, ferritin, was increased. Given that proteins that regulate the storage, transfer and release of iron play an important role in inflammation, this study aims to determine the serum and urine levels of ferritin and of the iron transfer protein, transferrin, in lup...

BACKGROUND A new serum marker of inflammation copeptin (CPP) a stable C-terminal pro-vasopressin was assessed along with conventional markers such as C-reactive protein (CRP), procalcitonin (PCT) and IL-6 to discriminate between lower and upper bacterial urinary tract infections (UTI). METHODS Study population comprised 45 patients including 13 with lower UTI (L-UTI) and 32 with upper UTI (U-...

BACKGROUND Atherosclerosis is a chronic inflammatory process resulting in coronary artery disease. OBJECTIVES To determine the relationship between inflammatory markers and the angiographic severity of CAD. METHODS We measured inflammatory markers in consecutive patients undergoing coronary angiography. This included C-reactive protein, fibrinogen, serum cytokines (interleukin-1 beta, IL-1 ...

UNLABELLED Background. Coronary heart disease (CHD) due to atherosclerotic inflammation remains a significant threat to global health despite the success of the lipid-lowering, anti-inflammatory statins. Tanshinone IIA, a potent anti-inflammatory compound derived from Traditional Chinese Medicine (TCM), may be able to supplement statins by further reducing levels of circulating inflammatory mar...

BACKGROUND The nuclear protein high-mobility group box 1 (HMGB1) is a key trigger for the inflammatory reaction during liver ischemia reperfusion injury (IRI). Hydrogen treatment was recently associated with down-regulation of the expression of HMGB1 and pro-inflammatory cytokines during sepsis and myocardial IRI, but it is not known whether hydrogen has an effect on HMGB1 in liver IRI. METHO...

Rosai-Dorfman disease (RDD) is a rare disorder characterized by the proliferation of histiocytes in the sinus of the affected lymph nodes, which leads to massive lymphadenopathy. RDD usually presents as an increased inflammatory response and lymph node swelling. We herein report the case of a hemodialysis patient with a fever, hypercalcemia and increased serum calcitriol level who was histologi...

Objective: Behcet's disease (BD) is a chronic inflammatory disorder characterized by recurrent oral and genital aphthous ulcers, uveitis and skin lesions. Oxidative stress and inflammation have important role in the pathogenesis of BD. The aim of this study was to assess the effect of Nigella sativa (NS) oil administration on malondialdehyde (MDA), total anti-oxidant c...

background and objectives: diabetes mellitus and periodontal disease are two chronic and common diseases with close relationship together affecting public health and quality of life. the aim of this study was to investigate the effect of resveratrol supplementation in adjunct with non-surgical periodontal treatment (nst) on blood glucose, triglyceride, periodontal status and inflammatory marker...

BACKGROUND An imbalance of cytokines is believed to contribute to the immunopathogenesis of inflammatory bowel diseases (IBD). Serum cytokine levels may correlate with disease activity and acute phase reactivity. AIM To determine the correlation of systemic interleukin-18 (IL-18) levels with disease activity and other markers of inflammation using a crosssectional pilot study in outpatients w...

Abstract Vitamin D deficiency (VDD) owing to its immunomodulatory effects is believed influence outcomes in COVID-19. We conducted a prospective, observational study of patients, hospitalized with Serum 25-OHD level < 20 ng/mL was considered VDD. Patients were classified as having mild and severe disease on basis the WHO ordinal scale for clinical improvement (OSCI). Of 410 patients recruite...