Flegel's disease, also known as hyperkeratosis lenticularis perstans, is a rare skin disease characterized by small reddish-brown asymptomatic hyperkeratotic papules usually located on the lower extremities. The histopathological features are hyperorthokeratosis, epidermal atrophy and band-like inflammatory infiltrate in the superficial dermis. Treatment is generally ineffective. We report a ca...

Langerhans cell histiocytosis is a dendritic cell disorder with a wide spectrum of severity and presentations. Histopathology typically demonstrates a proliferation of Langerhans cells and a lymphohistiocytic inflammatory infiltrate with eosinophils. The diagnosis is supported by immunohistochemistry with the cell markers S100, CD1a, CD68, and Langerin [Blood, 126, 2015, 26 and N Engl J Med, 33...

The Hermansky-Pudlak syndrome consists of albinism, platelet function defect, pigment laden macrophases and, on occasions, pulmonary fibrosis. The clinical course and postmortem findings of a patient with pulmonary fibrosis which mimicked cryptogenic fibrosing alveolitis are reported. Histological examination revealed a chronic inflammatory infiltrate of pigment laden microphages.

© 2013 The Authors. doi: 10.2340/00015555-1372 Journal Compilation © 2013 Acta Dermato-Venereologica. ISSN 0001-5555 Eosinophilic pustular folliculitis (EPF) is an inflammatory disease characterized by pruritic follicular papulopustules of unknown aetiology. Histopathologically, a number of eosinophils infiltrate around and into hair follicles. Nevertheless, EPF uncommonly affects the palms and...

To determine the role of endogenous interleukin-10 (IL-10) in local host defense during pneumococcal meningitis, the inflammatory responses of IL-10-gene-deficient and wild-type mice after the induction of meningitis were compared. The absence of IL-10 was associated with higher cytokine and chemokine concentrations and a more pronounced infiltrate, but antibacterial defense or survival was not...

Background: Diagnosis of the early phase of mycosis fungoides (MF) is sometimes difficult. Loss of CD7 expression is considered a distinguishing characteristic of MF. The aim of this study was to determine the range of CD7 expression in MF and compare the results with benign inflammatory dermatosis and equivocal cases of possible MF. Methods: During a period of 30 months, we examined 15 patient...

ABSTRACT: This study analyzed clinical and cyto-histomorphological parameters of the ocular surface Shih Tzu dogs, non-carriers carriers quantitative keratoconjunctivitis sicca (KCS) at different stages. Thirty-five eyes from 23 male female dogs between two eight years were evaluated in four groups: control group (CG - without KCS), mild KCS (KCS1), moderate (KCS2), severe (KCS3). Most variable...

BACKGROUND The local immune responses to chronic echinococcal infections in various organs are largely unknown. Since the liver is the most frequently involved organ in such infections in human we aimed to characterize the inflammatory as well as immune cell infiltrate around hydatid cysts in the liver and compared to common inflammatory processes of the liver. METHOD Surgical samples from th...