background: patients with ulcerative colitis (uc) carry autoantibodies such as perinuclear antineutrophil cytoplasmic antibodies (p-anca). objective: the aim of the present study was to evaluate the target antigens for p-anca in iranian patients with uc. methods: p-anca target antigens including elastase, lactoferrin, cathepsin g, myeloproxidase, lysozyme, and bactericidal permeability increasi...

background: it is claimed that the interaction of altering immune system bowel maturation, and measles vaccine predispose the body to inflammatory bowel diseasesalso it is proposed that breastmilk components during infancy, regulatemucosal immune activity to antigen and have protective role for ulcerative colitis and crohn's disease. materials and methods: this study was a case-control study. d...

he phenomenon of antiangiogenesis has attracted considerable interest in the scientific community. Angiogenesis plays a major role as a determining factor in a variety of diseases, including: cancer, arthritis, skin conditions, eye disorders, and inflammatory disease. The application of methods to manipulate angiogenesis has created fascinating therapeutic options, including the potential of na...

sally carried out for the treatment of non-congestive glaucoma. All over India glaucoma is very common but the general practitioner in India appears to be still unaware of the great frequency of this terrible disease. In the large eye hospitals in India very large numbers of people are operated on for the relief of glaucoma and the disease is far commoner throughout the Orient than in FAirope a...

Takayasu's disease is an idiopathic inflammatory arteriopathy involving the aorta and its main branches. Symptoms are related to vascular insufficiency of affected organs, especially the brain, eye, heart and kidneys. Major ocular complications consist of ischaemic retinopathy, complicated cataract and neovascular glaucoma. The definite diagnosis can be established by carotid doppler study or a...

A 33-year-old man was treated with systemic steroids for a retinal inflammatory lesion before the diagnosis of cryptococcal retinitis and meningitis was suspected. He died from central nervous system disease despite treatment with parenteral antifungals. Histopathological studies demonstrated ocular and disseminated systemic infection with Cryptococcus neoformans. Direct cryptococcal involvemen...

This review of general surgery has a distinctly abdominal flavour, with sections on the acute abdomen, inflammatory bowel disease, large bowel tumours, and diseases of the biliary system and pancreas. However, I also include peripheral vascular disease, the breast and experimental surgery as topics for discussion. As usual, the papers reviewed are those that particularly caught the author's eye...

Sarcoidosis is a chronic inflammatory disease with unknown cause characterized by non-caseating granuloma formations. It may present with bilateral hilar lymphadenopathy, skin lesions, the involvement of eye and symptoms on the locomotor system. FMF (Familial Mediterranean Fever) is an autosomal recessive autoinflammatory disease, characterized by recurrent episodes of fever and polyserositis. ...

Most irreversible blindness observed with glaucoma and retina-related ocular diseases, including age-related macular degeneration diabetic retinopathy, have their origin in the posterior segment of eye, making physiopathology both complex interconnected. In addition to age factor, these diseases share same mechanism disorder based essentially on oxidative stress. this context, imbalance between...

Cogan's syndrome is a rare idiopathic chronic inflammatory disease of the eye and the inner ear in young adults. Cogan's syndrome can be associated with large vessel vasculitis. We report a young female, with a history of interstitial keratitis and audiovestibular disease, who presents with large vessel vasculitis with left main coronary artery occlusion and develops heart failure. Cogan's synd...