Macrophage/microglia with heterogonous phenotype and function under physiological and pathological conditions are the main cell lineage involved in inducing immune responses in neuroinflammatory diseases which exhibit combined inflammatory and anti-inflammatory functions. An increase in the expression of iNOS triggers M1 phenotype that secrete high concentrations of inflammatory cytokines, whil...

Background & Aims: Dry type localized cutaneous Leishmaniasis due to Leishmania tropica is one of the most prevalent cutaneous parasitic infections in Kerman province. It seems that cellular immune response and the nature of immune inflammatory cells comprising the inflammatory background play a determinant role in this infection. Methods: Skin biopsies of 53 patients with acute(<2 years durati...

BACKGROUND: Due to their anti-inflammatory and immunomodulatory capabilities, mesenchymal stem cells (MSCs) are being widely used in cell-based therapies for the treatment of a wide spectrum inflammatory disorders. Despite promises, substantial cell loss post transplantation leads compromised therapeutic benefits clinical trials, which remains challenge overcome. Inflammatory microenvironment c...

mesenchymal stem cells (mscs),as the major stem cells for cell therapy, have been studied from different aspects in pre-clinical and clinical settings for more than a decade. these cells modulate the immune system (humoral and cellular immune responses) in vitro by producing soluble factors (anti-inflammatory molecules) and/or making cell-cell contacts. hence they could be used in regenerative ...

Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) such as Aspirin may have anticancer properties, and can be effective as a novel strategy for the treatment of colorectal cancer (CRC). The aim of this study was to assess the cytotoxic effects of Aspirin drug in CRC cell lines compared with Oxaliplatin drug in vitro. Methods: Cell viability was assessed after treatment of SW742 and SW48...

IgA vasculitis (IgAV) is a systemic, immune complex–mediated, small-vessel leukocytoclastic vasculitis. In the cutaneous tissue, it characterized by nonthrombocytopenic palpable purpura. Increasing evidence suggests importance of host immunity in its contribution to IgAV. However, molecular mechanisms tissue damage IgAV remain largely unknown. We performed single-cell RNA sequencing on biopsied...

Different bioinks have been used to produce cell-laden alginate-based hydrogel constructs for cell replacement therapy but some of these approaches suffer from issues with print quality, long-term mechanical instability, and bioincompatibility. In this study, new were developed grid-shaped stable integrity immunomodulating capacity. Integrity printability improved by including the co-block-poly...

IL-1 family member IL-37 inhibits both innate and adaptive immune responses. Previously, we have shown that intracellular expression in monocytes dendritic cells reduces inflammation induces tolerance. However, the role of extracellular on T cell activation remains unknown. Extracellularly, has been found to form a tripartite ligand-receptor complex containing IL-1R8 (SIGIRR/TIR8) IL-18Ra monoc...

Detrimental immune response has a crucially important role in the development and progression of inflammatory eye diseases. Inflammatory mediators proteolytic enzymes released by activated cells induce serious injury corneal epithelial retinal ganglion cell which may result vision loss. Mesenchymal stem (MSCs) are regulatory produce various immunosuppressive factors that modulate phenotype func...

Inflammation impacts human hematopoiesis across physiologic and pathologic conditions, as signals derived from the bone marrow microenvironment, such pro-inflammatory cytokines chemokines, have been shown to alter hematopoietic stem cell (HSCs) homeostasis. Dysregulated inflammation can skew HSC fate-related decisions, leading aberrant potentially contributing pathogenesis of hematological diso...