background considering the inadequacies of current therapeutic regimens for infantile spasms (is), and the frequent and serious side effects of  some regimens, the ongoing search for more enhanced protocols is understandable. materials and methods: we have compared the therapeutic and adverse effects of vitamin b6 given in high doses with those of prednisolone in a randomized controlled clinica...

Vigabatrin was approved for the treatment of infantile spasms by the US Food and Drug Administration, but not in Japan at the time of initiating this clinical study because of concerns about irreversible peripheral visual field defects (VFDs). This study evaluated the efficacy and safety of vigabatrin for Japanese patients with infantile spasms. Of 15 patients (aged ≥4weeks and <2years) enrolle...

Objectives The aim of the study was to describe the historical and clinical characteristics of hemangiomas in a series of cases of our clinic. Methods This is a retrospective study of 36 patients with infantile hemangiomas consulted in our clinic. Results We had 14 multiple hemangiomas, and 1 kaposiform hemangioendothelioma. Almost two-thirds involved the cephalic extremity, and 76% of the ...

AIM To describe how fetal growth and gestational age affect infantile colic, while considering other potential risk factors. STUDY DESIGN A population based follow up study of 2035 healthy singleton infants without any disability born to Danish mothers. Information was collected by self administered questionnaires at 16 and 30 weeks of gestation, at delivery, and 8 months post partum. Infanti...

While >200 types of etiologies have been shown to be involved in the pathogenesis of infantile spasms, the pathophysiology of infantile spasms remains largely elusive. Pre-natal stress and hypothalamic-pituitary-adrenal axis dysfunction were shown to be involved in the development of infantile spasms. To test the genetic association between the CRHR1 gene, which encodes the corticotrophin-relea...

OBJECTIVE To investigate the associations between use of nicotine replacement therapy (NRT) and smoking during pregnancy and infantile colic in the offspring. METHODS We used data from maternal interviews (from pregnancy and at 6 months post partum) from the Danish National Birth Cohort (1996-2002). We included 63 128 live-born singletons with complete information on nicotine exposure during ...

Background: Infantile spasms (IS) represent an age-specific epileptic disorder of infancy and early childhood. Children with infantile typically exhibit along the electroencephalographic (EEG) pattern known as roceededica. Although rare, 1.6 to 4.5 per 10,000 live births, IS is a significant because association developmental delay or regression, high mortality rate, refractoriness conventional ...

BACKGROUND AND PURPOSE Mutations in the PLA2G6 gene are causative of PLA2G6-associated neurodegeneration (PLAN), a spectrum of neurodegenerative conditions including infantile, childhood and adult onset forms. METHODS Seventeen North African patients with a clinical suspicion of infantile-onset PLAN underwent clinical, neurophysiological and neuroimaging examinations, and PLA2G6 sequencing. H...

Infantile hemangiomas, occurring at birth or during the first weeks of life, are benign vascular tumors with an initial proliferative phase and a later involutional phase. The massive proliferation on the key regions and unpredicted regression may threaten life. Thus, early management of infantile hemangiomas is necessary for affected infancies. Recent studies showed that propranolol for infant...

objective infantile spasms (is) is one of the catastrophic epileptic syndromes of infancy.the purpose of this study was to evaluate clinical efficacy and safety oftopiramate (tpm) as the first -line drug in the treatment of infantile spasms. materials and methods in a quasi- experimental study, efficacy and safety of tpm in rteatment of fortychildren with is who were referred to pediatric neuro...