The paper presents a hypothesis that the most probable cause of death ancient world Indus (Harappa) civilization was epidemic Asiatic cholera. A brief description existed for two millennia (3300–1300 BC) is given. It shown previously described factors decline thriving (climate change, shallowing river and reduction in floods, catastrophic drought, economic crisis, etc.) do not provide consisten...

The transformation of mature (urbanized) phase the ancient Indus civilisation between ?4200 and 3800 years Before Present (yr BP) overlaps with beginning Meghalayan Age (?4200 ± 100 yr BP). Though exact cause(s) for decline urbanized are not yet clear, researchers continue to debate whether monsoonal dryness was sole cause or several other regional factors manifested in a compounding manner. He...