results apoptosis induced by pa in ins-1 cells was significantly resolved after liraglutide treatment. simultaneously, autophagy was enhanced with the treatment of pa and liraglutide. conclusions: liraglutide appears to protect ins-1 cells from apoptosis ffa-induced by promoting autophagy. conclusions these findings provide a novel role for glp-1 analogue in preventing or treating with t2d. obj...

introduction: increased oxidative stress is widely accepted to be a factor in the development and progression of alzheimer’s disease. triazine derivatives possess a wide range of pharmacological activities including anti-oxidative and anti-in.ammatory actions. in this study, we aimed to investigate the possible protective effect of 3-thioethyl-5,6-dimethoxyphenyl-1,2,4-triazine (tedmt) on h2o2-...

Introduction Afatinib exhibits a tumor-inhibiting effect in different cancers by inducing apoptosis; however, its pro-apoptosis role glioma cells is still not fully understood. Material and methods In the current study, two cell lines (U373-MG U87-MG) were treated with afatinib to measure their tolerance for afatinib-triggered death apoptosis. Results We found that treatment repressed both grow...

Conducting cell apoptosis pathways is a novel strategy in cancer treatment. This study aimed to explain that C. botrys essential oil could induce apoptosis and arrest the cell cycle in HeLa cells. Cytotoxic and apoptogenic effects of the essential oil of Jerusalem-oak (Chenopodium botrys L.), which was obtained from the aerial parts of the plant, were evaluated in HeLa cells. Cell viability was...

ABSTRACT Apoptosis and inflammation were the main hallmarks of sepsis-induced cardiomyopathy (SIC). Yes-associated protein isoform 1 (Yap1) miR-484 involved in mitochondrial fission apoptosis, especially proapoptotic roles SIC. Here, we investigated role Yap1 lipopolysaccharide (LPS)-treated H9c2 cells. was downregulated, while elevated by LPS treatment. Cell counting kit-8, flow cytometry, wes...

Purpose: To investigate the involvement of aldo-keto reductase family 1 member C1 (AKR1C1) in glycyrrhizic acid-mediated gastric cancer.Methods: Immunohistochemistry, quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR), and western blot were used to assess AKR1C1 expression cancer. Cell proliferation was assessed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-te...

In retinal organ cultures, H2O2 can be used to simulate oxidative stress, which plays a role in the development of several diseases including glaucoma. We investigated whether processes underlying stress prevented cultures by an inducible nitric oxide synthase (iNOS)-inhibitor. To this end, porcine explants were cultivated for four and eight days. Oxidative was induced via 300 µM on day one thr...


 Purpose: To investigate the action of miR-483-3p in pediatric pneumonia and identify potential biomarkers.
 Methods: Bronchoalveolar lavage was collected from 38 patients 25 healthy children. The expression determined using qRT-PCR. Alveolar macrophages children were cultured used for functional assays. Transwell assay conducted to evaluate macrophage cell migration. Cell viability ...

Conducting cell apoptosis pathways is a novel strategy in cancer treatment. This study aimed to explain that C. botrys essential oil could induce apoptosis and arrest the cell cycle in HeLa cells. Cytotoxic and apoptogenic effects of the essential oil of Jerusalem-oak (Chenopodium botrys L.), which was obtained from the aerial parts of the plant, were evaluated in HeLa cells. Cell viability was...