the present study was performed to explore the matrix property of ficus glomerata fruit mucilage for making transdermal patches. the mucilage was evaluated for its physicochemical properties. various transdermal patches of indomethacin were prepared by solvent evaporation technique using different proportions of f. glomerata fruit mucilage. the compatibility studies between indomethacin and f. ...

1. The acute haemodynamic and hormonal effects of 100 mg of captopril (SQ 14.225) orally were tested in twelve healthy men in the sodium replete state before and after indomethacin pretreatment. 2. Without indomethacin, mean arterial blood pressure was reduced at 30 and 60 min after captopril (P less than 0.02). Heart rate did not change during the whole experiment. Although plasma renin activi...

Introduction: The incidence rate of gastric erosions and ulcers in diabetic patients are higher due to failure of mucosal antioxidant defense and maintain enough blood flow. The present study evaluated the gastro-protective effect of sodium hydrosulfide (NaHS) against indomethacin-induced gastric lesions in diabetic rats. Methods: In order to test anti-ulcer activity of NaHS against indomet...

Class of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs), includes Anaprox (naproxen), Ansaid (flurbiprofen), Arthrotec (diclofenac sodium/misoprostil), Caldolor (ibuprofen), Cambia (diclofenac potassium), Cataflam (diclofenac), Celebrex (celecoxib), Daypro (oxaprozin), Daypro Alta (oxaprozin), Duexis (ibuprofen and famotidine), Dyloject (diclofenac), Feldene (piroxicam), Flector (diclofenac), In...

Orally ingested non-steroidal anti-inflammatory drugs (NSAIDs) and acid in gastric secretions are gastric irritants that co-exist at the surface of the gastric mucosa. Here, we examined the individual and combined effects of indomethacin, a typical NSAID, and hydrochloric acid on cell death in primary cultures of guinea pig gastric mucosal cells. Indomethacin alone (at concentrations less than ...

Four boys with classical nephrogenic diabetes insipidus have been treated by indomethacin, by hydrochlorothiazide, and by the combination of indomethacin and hydrochlorothiazide. Hydrochlorothiazide treatment was slightly more effective than indomethacin treatment in reducing the urine volume and increasing the urine osmolality. The combination of indomethacin and hydrochlorothiazide appeared t...

Gastric ulcers are a common gastrointestinal disease with complex etiology. It manifests various signs and symptoms, which, in severe cases, could be life-threatening, especially developing countries. Medicinal plants have been known to exhibit therapeutic potential minimal adverse effects thus employed treating diseases. This study evaluated the effect of ethanolic Myrianthus arboreus leaf ext...

PURPOSE To investigate the effect of indomethacin inhibition of prostanoid production on the epinephrine-stimulated increase in outflow facility and cyclic adenosine monophosphate (cAMP) production in the anterior segment of the monkey eye. METHODS Topical indomethacin was given 1 hour before the intracameral administration of epinephrine to living cynomolgus monkeys. Outflow facility was mea...