We develop expressions for the power to detect associations between parental genotypes and offspring phenotypes for quantitative traits. Three different "indirect" experimental designs are considered: full-sib, half-sib, and full-sib-half-sib families. We compare the power of these designs to detect genotype-phenotype associations relative to the common, "direct," approach of genotyping and phe...

Background Primary Sjögren’s Syndrome (pSS) is characterised by oral and ocular dryness, possible development of systemic manifestations, increased lymphoma risk, a highly diverse patient burden. To address this heterogeneity Tarn identified four endotypes based on patient-reported symptoms fatigue, pain, anxiety depression: low symptom burden (LSB), pain dominant with fatigue (PDF), dryness (D...

OBJECTIVES This study was conducted to estimate the socioeconomic cost of injuries in South Korea. METHODS We matched claims data from national health insurance, automobile insurance and industrial accident compensation insurance (IACI), and mortality data obtained from the national statistical office from 2001 to 2003 by patients' unique identifier. Socioeconomic cost included both direct co...