In the last decades the prevalence of non-alcoholic fatty liver disease (NAFLD) has increased as a consequence of the childhood obesity world epidemic. The liver damage occurring in NAFLD ranges from simple steatosis to steatohepatitis, fibrosis and cirrhosis. Recent findings reported that fatty liver disease is related to early atherosclerosis and cardiac dysfunction even in the pediatric popu...

covered at the post-mortem examination. The woman was sixty years of age, and showed signs of general atheroma. There was no history of injury, but most of her organs were more or less diseased, and she appears to have died from a combination of pleural effusion and hepatic cirrhosis. Dr. Joseph Walsh contributes an interesting paper on Pertussis, one of the gravest troubles of childhood. Unfor...

BACKGROUND Treatment with interferon-alpha (IFN) has been shown to be cost-effective in developed countries. However, cost-effectiveness In developing countries such as India has not been studied. METHODS Using the Markov transitional probability model, we studied two cohorts of young patients (30 years of age) with chronic hepatitis B, one untreated and the other treated with interferon (IFN...

Even though most of the Indian population lives in a joint family system, where focus attention for is child; still smoking childhood and adolescence very much prevalent. What disturbing about this fact, three-quarters adolescents who smoke frequently carry on as adults. It brings us to point that, do we need think any other alternative, or shift our some direction? Should be shifted from habit...

background serum apoptotic cytokeratine 18 neoepitope m30 (ck-18 m30) and matrix metalloproteinase 2 (mmp-2) have been popular markers for detecting liver fibrosis in recent years. ck-18 is a major intermediate filament protein in liver cells and one of the most prominent substrates of caspases during hepatocyte apoptosis. mmp-2 plays an important role in tissue remodeling and repairing process...

introduction: acute lymphoblastic leukemia (all ) is the most worldwide common type of childhood cancer. methylenetetrahydrofolate reductase (mthfr) and 5-methyltetrahydrofolate-homocysteine methyltransferase (mtr) are crucial enzymes in folate pathways. folate availability is critical factor for dna integrity, required for the transfer of methyl group in the biosynthesis of thymidilate. proced...

Primary biliary cirrhosis (PBC) is an autoimmune disease of the liver, characterized by the presence of antimitochondrial antibodies (AMA) and progressive immune-mediated destruction of biliary ductules, which lead to cirrhosis. Theories of the PBC etiopathogenesis assume that the disease develops secondarily as an improper immunological reaction to undefined environmental and/or infectious fac...

Ascites is a poorly understood postoperative complication of orthotopic liver transplantation (OLT). It is associated with additional morbidity and can prolong hospitalization considerably. The incidence, the factors predictive of occurrence and the etiology of this complication are not known. The charts of 118 patients with 138 OLT were analyzed according to the following criteria: ascites las...

C3 exhibits two common allotypic variants that may be separated by gel electrophoresis and are called C3 fast (C3 F) and C3 slow (C3 S). C3 F, the less common variant, occurs at appreciable frequencies only in Caucasoid populations (gene frequency = 0.20). An increased prevalence of the C3 F allele has been reported in patients with partial lipodystrophy, IgA nephropathy, and Indian childhood h...