We have previously shown that in some patients with primary hyperoxaluria type 1 (PH1), disease is associated with mistargeting of the normally peroxisomal enzyme alanine/glyoxylate aminotransferase (AGT) to mitochondria (Danpure, C.J., P.J. Cooper, P.J. Wise, and P.R. Jennings. J. Cell Biol. 108:1345-1352). We have synthesized, amplified, cloned, and sequenced AGT cDNA from a PH1 patient with ...

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Abstract It is widely accepted that knowledge incompatible with the presence of non-neutralized defeaters. A common way addressing this issue to introduce a condition effect there are no defeaters for belief p (i.e. “no-defeaters condition”). I argue meeting leaves open possibility squander our knowledge. The no-defeaters can be fortuitously met, and as result it met luckily. shall kind luck in...

Heavy meromyosin (HMM) of myosin II and cofilin each binds to actin filaments cooperatively and forms clusters along the filaments, but it is unknown whether the two cooperative bindings are correlated and what physiological roles they have. Fluorescence microscopy demonstrated that HMM-GFP and cofilin-mCherry each bound cooperatively to different parts of actin filaments when they were added s...

OBJECTIVE To study the modulation of somatosensory evoked potentials (SEP) using transcranial magnetic intermittent theta burst stimulation (iTBS) over human primary motor (M1) and sensory (S1) cortices. METHODS Eleven healthy subjects participated in the study. Median nerve SEP were elicited by electrical stimulation at the right wrist before and after 600-pulse iTBS over M1 or S1 of the lef...

Vegetative propagation of potato allows the dissemination of viruses that can cause drastic drops in tuber yield. Potato virus Y (PVY) is one of the most important viruses of potato due to the non-persistent mode of transmission through vector insects. Genetic resistance is the recommended control measure since the chemical control of vector insects is not effective. This study aimed to identif...

We examined four cardiomyopathy-causing mutations of troponin I that appear to disturb function by altering the distribution of thin filament states. The R193H (mouse) troponin I mutant had greater than normal actin-activated myosin-S1 ATPase activity in both the presence and absence of calcium. The rate of ATPase activity was the same as that of the wild-type at near-saturating concentrations ...