BACKGROUND Impaired wound healing is a well-documented phenomenon in experimental and clinical diabetes. Emerging evidence favors the involvement of free radicals in the pathogenesis of diabetes-related healing deficit. This study assessed the effect of systemic administration of raxofelast, a protective membrane antioxidant agent, on wound healing by using healing-impaired (db/db) mice. METH...

Abstract Introduction Ventral hernia repair is one of the challenging surgical operations over time. It suggested that sublay mesh has lowest recurrence and site infection in open anterior abdominal repair. This study aimed to analyse pros cons ventral evaluate significance this technique as a treatment modality. Hospital stay, acute postoperative complications, rate were main areas investigati...

background langerhans cell histiocytosis (lch) is a rare disease in which monoclonal migration and proliferation of specific dendritic cells is seen. the disease primarily affects the bones and skin, but there is a possibility that involves other organs or appears as a multi-systemic disease. case report in oral examination of a nine-month girl, two deep wounds with a yellow membrane with appro...

In this study, we investigated the effects of total ginseng saponin (TGS) on the cutaneous wound healing process using histological analysis. A total of 24 ICR mice, 5-weeks-old, were used for all in vivo experiments. Mice were divided into control and TGS-treated groups and four equidistant 1-cm full-thickness dorsal incisional wounds were created. The wounds were extracted at days 1, 3, 5, an...

OBJECTIVE Recent developments of negative pressure wound therapy (NPWT) systems have focused on making pumps smaller, lighter, and more portable. The recently introduced PICO system manages wound fluid through a highly breathable film within the dressing, thereby negating the need for a canister, which allows greater mobility and patient concordance. The aim of this study is to compare the biol...

Leptin, a 16 kDa pleiotropic cytokine primarily expressed in adipose tissue, has been shown to cause multiple systemic biological actions. Recently, leptin has also been documented as an important component of the wound healing process and its receptor appears to be expressed in wound tissue. We have previously demonstrated that leptin is a potent angiogenic factor exerting direct effects on en...

Background: Abdominal wound dehiscence (AWD) is a severe postoperative complication associated with high mortality and morbidity. Prolonged hospital stay, high incidence of incisional hernia, and subsequent reoperations underline the severity of this complication. The goal of the underlying study was to evaluate possible risk factors for abdominal wound dehiscence and its management. Methods: T...

OBJECTIVES To investigate the effect of skin incision location for total laryngectomy with pharyngectomy (TLP) on postoperative outcomes including wound dehiscence and infection rate. STUDY DESIGN Case series with chart review. SETTING Academic tertiary care center. METHODS A retrospective analysis was conducted of all patients undergoing TLP with flap closure at Johns Hopkins Medical Ins...

OBJECTIVE To report our experience with the use of Proceed™, Ethicon, Norderstedt, Germany surgical mesh in the management of large abdominal wall defects with the open intra-peritonium onlay method. METHODS Thirty-six patients with large incisional hernia or defects resulting from tumor resection carried out at the Department of General Surgery, the First Affiliated Hospital, General Hospita...

BACKGROUND We prospectively investigated whether the wound-protective Alexis (Applied Medical, Rancho Santa Margarita, CA) wound retractor was effective in preventing surgical site infection (SSI). METHODS We examined the actual condition of SSI in a 12-month randomized, controlled trial consisting of 221 patients who had undergone nontraumatic gastrointestinal surgery. The patients were divi...