In the present investigation an attempt has been made to increase therapeutic efficacy, to reduce frequency of administration and to improve patient compliance by developing a sustained release matrix tablets of isosorbide-5-mononitrate. Sustained release matrix tablets of isosorbide-5-mononitrate were developed by using different drug: polymer ratios, such in F1 (1:0.75), F2 (1:1), F3 (1:1.5),...

In the present investigation an attempt has been made to increase therapeutic efficacy, to reduce frequency of administration and to improve patient compliance by developing a sustained release matrix tablets of isosorbide-5-mononitrate. Sustained release matrix tablets of isosorbide-5-mononitrate were developed by using different drug: polymer ratios, such in F1 (1:0.75), F2 (1:1), F3 (1:1.5),...

This paper presents results of a pharmacokinetics study concerning pentoxifylline and its main metabolites after administration of extended release formulation of Trental 400 mg and correlation of this pharmacokinetics with in vitro dissolution test results of parent drug. In order to establish most relevant in vitro test, dissolution was performed in different experimental conditions (stirring...

We recently reported that rodent hippocampal slices incubated with levetiracetam for 3h had altered responses to repetitive stimulation and reduced neurotransmitter release. However, our experiments failed to determine the actual time course of diminished transmission in individual slices followed over time. We have now been able to record from the same slices for up to 3h to determine the late...

Propanidid followed by intravenous atropine and suxamethonium induced anaphylaxis in a 29-year-old woman. The patient had previously been exposed to suxamethonium and atropine but the episode reported here occurred after initial exposure to propanidid. The patient's leucocytes eight weeks after anaesthesia released histamine in vitro in the presence of both propanidid and atropine. Histamine re...

The main purpose of the present study was to develop ocuserts of Fluconazole β-CD (beta-cyclodextrin) complex and to evaluate both in vitro and in vivo. Fluconazole was made complex with β-CD, and the release rate was controlled by HPMC K(4)M and ethyl cellulose polymers using dibutyl Phthalate as permeability enhancer. Drug-polymer interactions were studied by Fourier transform infrared spectr...

We examined the inhibitory effect of the extract of kakrol extracted by 3 types of solvent (water, 50% and 100% ethanol) on histamine release in human basophilic KU812 cells. The water extract of kakrol flesh showed the strongest inhibitory effect on histamine release as compared with the other extracts. Therefore, we evaluated whether water extract of kakrol flesh had a suppressive effect on d...

Two mechanisms have been described whereby rabbit platelets in vitro may be induced to release their contained histamine by the reaction of antigen and antibody. Both processes require the participation of the complement system. In the first, the adherence of platelets to particulate antigens such as zymosan or erythrocytes which have fixed complement through the third component was followed by...