Acetylsalicylic acid (ASA), the most used drug worldwide, is hydrolyzed to salicylic acid and acetate by esterases present in tissues of several species including humans. Sex differences in drug metabolism by rodent liver are documented in the literature. In this paper we report a difference in the activities of the esterases (ASA-esterase I and II) in the kidneys of male and female mice. In th...

Varroa mites (Varroa destructor Anderson and Trueman, 2000) are becoming resistant to acaricide treatments via metabolic and/or target site desensitivity. Results of a survey of mites from the Carl Hayden AZ lab and from cooperators in five locations (Arizona, California, Florida, Maine, North Dakota) showed that some mites were susceptible to all three acaricides (Amitraz, Coumaphos, Fluvalina...

Human liver aldehyde dehydrogenase has been found to be capable of hydrolyzing p-nitrophenyl esters. Esterase and dehydrogenase activities exhibited identical ion exchange and affinity properties, indicating that the same protein catalyzes both reactions. Competitive inhibition of esterase activity by glyceraldehyde and chloral hydrate furnished evidence that p-nitrophenyl acetate was hydrolyze...

Plasma thromboplastin antecedent (PTA, factor XI) is an important intermediate in the intrinsic coagulation system, and plasma kallikrein has been implicated as a mediator of the inflammatory process. Whereas their biologic activities are functionally distinct, their identity as separate entities in plasma has not been fully established, and the nature of their plasma inhibitors has not been co...

Control of the horn fly, Hematobia irritans (L.), is generally dependent on chemical insecticides. However, the biology and behavior of the horn fly favors rapid development of insecticide resistance. To prolong the effectiveness of the insecticide option, information is required regarding the mechanisms of insecticide resistance. Metabolic hydrolysis of insecticides by esterases is a detoxific...

The isolate DVL2 was isolated from common city garbage using the tributyrin as substrate. The isolate resulted in orange fluoresce under UV light on rohodamine olive oil agar plate detecting the lipase production. Three production media (PM1, PM2 and PM3) were evaluated for lipase/esterase production. In culture filterate (extracellular enzyme) and cell free extract i.e. extract after sonicatio...

BACKGROUND & OBJECTIVES Anopheles stephensi and A. culicifacies are the two major vectors of malaria in Karnataka. These mosquito populations are continuously being exposed directly or indirectly to different insecticides including the most effective pyrethroids. Therefore, there is a threat of insecticide resistance development. We subjected these vectors to larval bioassay using two popular p...