OBJECTIVE This paper examines the current literature pertaining to brain ageing. The objective of this review is to provide an overview of the effects of ageing on brain structure and function and to examine possible mediators of these changes. METHODS A MEDLINE search was conducted for each area of interest. A selective review was undertaken of relevant articles. RESULTS Although fundament...

Somerset Maugham is well known for his literary skills as a best-selling author. But many may not know that he studied medicine and qualified as a surgeon at St Thomas’s Hospital, London. It is no wonder that in his book “Of Human Bondage”, Maugham wrote of a lecturer advising first-year medical students that, “You will have to learn many tedious things which you will forget the moment you have...

The past year has witnessed refinements in models of spliceosome assembly pathways and in the understanding of how splicing factors of the serine/arginine-rich (SR) protein family function. The role of splicing in human genetic diseases has also received a lot of attention recently as exonic splicing enhancers become better understood.

Of course, from childhood to forever, we are always thought to love reading. It is not only reading the lesson book but also reading everything good is the choice of getting new inspirations. Religion, sciences, politics, social, literature, and fictions will enrich you for not only one aspect. Having more aspects to know and understand will lead you become someone more precious. Yea, becoming ...

In business, as in the government and tertiary sectors, unlocking mechanisms for ‘life-long’ learning is without question one of the major challenges of today. Each of these sectors must recognise the criticality of preparing people for the world as it is and it is likely to be as opposed to that which is rapidly vanishing. Institutions which fail to grasp this reality have what is surely a bri...

2 AI in a New Millennium: Obstacles & Opportunities 2 2.1 AI as both Science and Engineering . . . . . . . . . . . . . . . . . . . . 2 2.2 Difficulties and how to address them. . . . . . . . . . . . . . . . . . . . . 4 2.3 Institutional and financial obstacles . . . . . . . . . . . . . . . . . . . . . 4 2.4 Failing to see problems: ontological blindness . . . . . . . . . . . . . . . 5 2.4.1 Wha...

Background: Recently, multileaf collimators (MLC) have become an important part of any LINAC collimation system because they reduce the treatment planning time and improve the conformity. Important factors that affect MLCs collimation performance are leaves material composition and their thickness.Objective: In this study, we investigate main dosimetric parameters of a typical MLC includi...