An increasing proportion of healthcare resources in the United States are directed toward an expanding group of complex and multimorbid patients. Federal stakeholders have called for new models of care to meet the needs of these patients. Minimally Disruptive Medicine (MDM) is a theory-based, patient-centered, and context-sensitive approach to care that focuses on achieving patient goals for li...

Mechanical folding trajectories for polyproteins starting from initially stretched conformations generated by single-molecule atomic force microscopy experiments [Fernandez, J. M. & Li, H. (2004) Science 303, 1674-1678] show that refolding, monitored by the end-to-end distance, occurs in distinct multiple stages. To clarify the molecular nature of folding starting from stretched conformations, ...

Previous investigations have revealed that eccentric super-Earths represent a class of planets which are particularly effective at transporting minor bodies towards white dwarfs and subsequently polluting their atmospheres with observable chemical signatures. However, the lack discoveries these beyond few astronomical units from host stars prompts better understanding orbital architectures nasc...

1. Describe the impact of multiple chronic conditions on individual patients and on the health care system. 2. Discuss the contributions of the interdisciplinary health care team members in the management of chronic disease. 3. Summarize the common medication-related problems occurring in older adults, focusing on falls. 4. Define the impact of medication non-adherence to the treatment plan in ...

It is estimated that 75% of the population in industrialised countries will die from chronic diseases and most of them with multiple chronic conditions [2]. End of life care for multimorbid patients is particularly complex and in most health and care systems fragmented and uncoordinated. More importantly, highly medicalised and hospital-centric care often leads to overtreatment and over use of ...

BACKGROUND The needs of the growing population of complex patients with multiple chronic conditions calls for a different approach to care. Clinical teams need to acknowledge, respect, and support the work that patients do and the capacity they mobilize to enact this work, and to adapt and self-manage. Tools that enable this approach to care are needed. METHODS Using user-centered design prin...

This article offers national estimates of the proportions of hospital inpatient cases and cost for adult, nonmaternal patients who have multiple chronic conditions. The authors employ a refined classification of chronic versus acute conditions, collapsed to no more than one condition per distinct category of condition. The number of different chronic conditions provides a simple measure of comp...

©2004 Association of Schools of Public Health In 2000, approximately 125 million Americans (45% of the population) had chronic conditions and 61 million (21% of the population) had multiple chronic conditions. The number of people with chronic conditions is projected to increase steadily for the next 30 years. While current health care financing and delivery systems are designed primarily to tr...

Asian-Americans are a small but fast-growing population in the United States who are increasingly experiencing multiple chronic diseases. While the evidence-based Chronic Disease Self-Management Program (CDSMP) has been disseminated among various racial and ethnic populations, few studies specifically investigate participants with an Asian background. The study aims to identify characteristics ...

BACKGROUND Drug is an important part of disease treatment, but medication errors happen frequently and have significant clinical and financial consequences. The prevalence of prescription medication use among the ambulatory adult population increases with advancing age. Because of the global aging society, outpatients need to improve medication safety more than inpatients. OBJECTIVE The elder...