Abstract Implantation depends on bi-directional communication between the blastocyst and endometrium. Encoded in this is information maternal embryonic fitness, which turn can lead to activation of species-specific reproductive suppression mechanisms. For example, blastocysts over 130 mammals, although not humans, respond presence or absence specific endocrine endometrial cues by entering exiti...

ObjectiveTo present a definition of recurrent implantation failure that accounts for the effects female age and anticipated blastocyst euploidy rates on cumulative rates.DesignMathematical modeling.SettingNot applicable.Patient(s)Not applicable.Intervention(s)Mathematical modeling probability basis published across categories age.Main Outcome Measure(s)The number blastocysts required to achieve...

a 29-year-old woman was referred to our hospital due to exacerbation in dyspnea on exertion and easy fatigability. a known case of congenitally corrected transposition of the great vessels and congenital complete heart block, she had already received a permanent single-chamber pacemaker. decision was made to implant a biventricular pacemaker for the treatment of the failing heart. excellent cor...

conclusions switching ams off may increase biventricular pacing in some patients. case presentation in this case series, we present a combination of far field sensing and automatic mode switching (ams) in six patients. it is found that this combination causes ventricular sensing (vs) episodes with wide qrs and no synchronization. we turn off the ams and alleviate the problem. introduction cardi...

Abstract The EUROMACS Right-Sided Heart Failure Risk Score was developed to predict right ventricular failure (RVF) after left assist device (LVAD) placement. predictive ability of the score has not been tested in other cohorts. We performed a single center analysis continuous-flow (CF) LVAD cohort (n = 254) where we calculated risk scores and assessed for heart implantation. Thirty-nine percen...

OBJECTIVE Even in the era of high output implantable cardioverter defibrillator (ICD) devices, a certain proportion of patients cannot be successfully defibrillated with 10 J safety margin. In practice, either the use of a single- or double-coil lead does not guarantee successful termination of induced ventricular fibrillation. Therefore, we investigated the effectiveness of the subcutaneous fi...

Embryo implantation represents the most critical step of the reproductive process in many species. Inadequate uterine receptivity is responsible for approximately two-thirds of implantation failures. The cell adhesion molecule (CAM) such as integrins, cadherins, selectins and immunoglobulins intervene to ensure adhesiveness between the embryo and the endometrium. Some recent studies indicate th...

Implantation failure and early pregnancy loss have been reported to be closely related to the quality of mammalian oocytes; however, the pregnant outcome of embryos from in-vitro matured (IVM) oocytes remains unknown. In this study we examined spindle assembly and chromosome segregation during differentiation, and the duration of IVM of mouse oocytes. The resulting implantation and pregnancy ou...