نتایج جستجو برای: immunosuppressive factor
تعداد نتایج: 863068 فیلتر نتایج به سال:
Prosthetic joint infection (PJI) occurs with significant morbidity and health care expenditure. Transplant recipients on immunosuppressive medications are at increased risk for infections caused by less common organisms at unusual sites. Here we report a case of isolated PJI with Mycobacterium avium complex (MAC) in an immunosuppressed failed kidney transplant recipient and review the literatur...
It has recently been reported that the CD40-CD40 ligand (CD40L) interaction is important in Th17 development. In addition, transforming growth factor-beta (TGF-β) promotes tumorigenesis as an immunosuppressive cytokine and is crucial in the development of Th17 cells. This study investigated the role of CD40 in breast cancer cells and its role in immunosuppressive function and tumor progression....
Therapeutic options for hepatitis C virus (HCV) infection have been limited by drug resistance and adverse side effects. Targeting the host factor cyclophilin A (CypA), which is essential for HCV replication, offers a promising strategy for antiviral therapy. However, due to its immunosuppressive activity and severe side effects, clinical application of cyclosporine A (CsA) has been limited as ...
The aim of this study was to evaluate the local immune status of human ovarian cancers by the comprehensive analysis of tumor-infiltrating immune cells and immunosuppressive factors, and to elucidate the local immunity in clinical course. The numbers of CD1α+, CD4+, CD8+, CD57+, forkhead box P3+ and programmed cell death-1+ cells were counted, and the intensity of immunosuppressive factors, suc...
Introduction: Wegener’s Granolomatosis (WG) is a systemic, necrotizing, small-vessel vasculitis. Vascular inflammation and occlusion leading to tissue ischemia is a hallmark of WG. WG has a clinical predilection for the upper airways, lungs, and kidneys. Thromboembolic events do not usually occur and arterial thrombosis is extremely rare. Case Report: Here we reported 2 rare cases of arteria...
background and aim: steroid-resistant nephrotic syndrome (srns) accounts for 10%-20% of all cases of idiopathic nephrotic syndrome. these patients are at risk of developing end-stage renal disease. the aim of this study was to determine the demographic characteristics, renal biopsy findings, response to immunosuppressive treatment, and prognosis in pediatric patients with srns.materials and met...
در سال های اخیر، کاربرد مدل های هیدرولوژیکی توزیعی بر پایه فیزیکی افزایش یافته است. با این حال بسیاری از سوالات در خصوص واسنجی و صحت سنجی صحیح مدل های توزیعی و ارزیابی عدم قطعیت پارامترهای تخمینی، هنوز هم ناشناخته است. به خصوص برای مدل های پیچیده، تخمین پارامترها به طور صحیح، کاهش فضای پارامتری و استفاده از الگوریتم های موثر و کارآمد به منظور کاهش عدم قطعیت و تسهیل فرآیند واسنجی امری ضروریست. ه...
در این تحقیق به بررسی پارامترهای بیلان آب حوضه رودخانه آق چای در شمال استان آذربایجان غربی، با مساحت 1440.89 کیلومتر مربع پرداخته شده است. مدل سازی بارش-رواناب با گام زمانی روزانه و با استفاده از مدل نیمه توزیعی swat و بهینه سازی پارامترهای حوضه، بررسی عدم قطعیت مدل و پارامترها با برنامه swat-cup انجام گرفته است. کاربرد الگوریتم sufi-2 در بررسی عدم قطعیت نشان داد مقدار ضریب ناش برای دوره واسنج...
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