Last December, a novel coronavirus emerged in Wuhan city, China. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes high intense with elevation mortality. Nucleocapsid phosphoprotein (NP) is one of the most structural proteins virus. NP possesses active immunogenicity for T-cell response. Because considered as potential vaccine target, our study goal was to identify cytotoxic (...

Contagious human coronavirus belong to family Coronaviridae and infects respiratory system causing the disease known as COVID-19 (WHO). To eradicate severe acute syndrome 2 pandemic, an effective vaccine should be developed. In current study immunoinformatics procedures were employed introduce a novel multi-epitope subunit vaccine. This can activate equally class I II leukocyte antigen antibody...

Rotavirus is the most common cause of severe infant and childhood diarrhea worldwide, and the morbidity and mortality rate is going to be outnumbered in developing countries like Bangladesh. To mitigate this substantial burden of disease, new therapeutics such as vaccine and drug are swiftly required against rotavirus. The present therapeutics insight study was performed with comprehensive immu...

Visceral leishmaniasis (VL) or kala-azar, a vector-borne protozoan disease, shows endemicity in larger areas of the tropical, subtropical and the Mediterranean countries. WHO report suggested that an annual incidence of VL is nearly 200,000 to 400,000 cases, resulting in 20,000 to 30,000 deaths per year. Treatment with available anti-leishmanial drugs are not cost effective, with varied efficac...

Crimean-Congo hemorrhagic fever virus (CCHFV), the fatal human pathogen is transmitted to humans by tick bite, or exposure to infected blood or tissues of infected livestock. The CCHFV genome consists of three RNA segments namely, S, M, and L. The unusual large viral L protein has an ovarian tumor (OTU) protease domain located in the N terminus. It is likely that the protein may be autoproteoly...