نتایج جستجو برای: immune mediated thrombocytopenia

تعداد نتایج: 656572  

Journal: :Current protocols in immunology 2016
Anton Neschadim Donald R Branch

Immune thrombocytopenia (ITP) is a debilitating, life-threatening autoimmune disorder affecting more than 4 in every 100,000 adults annually, stemming from the production of antiplatelet antibody resulting in accelerated platelet destruction and thrombocytopenia. Numerous animal models of ITP have been developed that contributed to the basic understanding of the underlying mechanisms of ITP ons...

Journal: :Journal of thrombosis and haemostasis : JTH 2012
S Lakshmanan A Cuker

Immune thrombocytopenia (ITP) comprises a syndrome of diverse disorders that have in common immune-mediated thrombocytopenia, but that differ with respect to pathogenesis, natural history and response to therapy. ITP may occur in the absence of an evident predisposing etiology (primary ITP) or as a sequela of a growing list of associated conditions (secondary ITP). Primary ITP remains a diagnos...

2012
Jeevan Kumar Manorama Bhargava Shyam Aggarwal

We report a case of bevacizumab- (BEV-) induced thrombocytopenia in a 59-year-old man with adenocarcinoma of colon. After colectomy, the patient was treated with twelve cycles of FOLFOX-4 (folinic acid, 5-fluorouracil, and oxaliplatin) regimen. On relapse, he was treated with FOLFIRI (folinic acid, 5-fluorouracil, and irinotecan) regimen along with BEV 10 mg/kg for 6 cycles. After that, BEV was...

Journal: :Journal of Ayub Medical College, Abbottabad : JAMC 2009
Shuaib Ansari Haji Khan Khoharo Allauddin Abro Israr Ahmd Akhund Fatima Qureshi

BACKGROUND Malaria is usually associated with reduced blood cell counts & mild to moderate thrombocytopenia is a common association of malaria. The cause of thrombocytopenia is poorly understood, but the immune-mediated lysis, sequestration in the spleen and dyspoietic processes in the marrow with diminished platelet production have all been postulated. This study was conducted to evaluate thro...

Journal: :Pediatria polska 2021

ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA KsiÄ Å¼ek A, Szczepański T. Primary immune thrombocytopenia in children. Pediatria Polska - Polish Journal of Paediatrics. 2021;96(1):53-59. doi:10.5114/polp.2021.104829. APA żek, A., & Szczepański, (2021). Paediatrics, 96(1), 53-59. https://doi.org/10.5114/polp.2021.104829 Chicago Agnieszka, and Tomasz Szczepa...

Journal: :Haematologica 2016
Lamiae Grimaldi-Bensouda Clémentine Nordon Marc Michel Jean-François Viallard Daniel Adoue Nadine Magy-Bertrand Jean-Marc Durand Philippe Quittet Olivier Fain Bernard Bonnotte Anne-Sophie Morin Nathalie Morel Nathalie Costedoat-Chalumeau Brigitte Pan-Petesch Mehdi Khellaf Antoinette Perlat Karim Sacre François Lefrere Lucien Abenhaim Bertrand Godeau

This prospective observational cohort study aimed to explore the clinical features of incident immune thrombocytopenia in adults and predictors of outcome, while determining if a family history of autoimmune disorder is a risk factor for immune thrombocytopenia. All adults, 18 years of age or older, recently diagnosed with immune thrombocytopenia were consecutively recruited across 21 hospital ...

2017
Julia Cavalcante do Carmo Prissyla de Souza Klippel Sabrine da Costa Cordeiro Ângela Maria dos Santos Fernandes Raquel Medeiros Pinto Simone Schneider Weber Cleiton Fantin

BACKGROUND Immune thrombocytopenia is an immune disease characterized by thrombocytopenia and bleeding due to platelet antibodies against platelet membrane glycoproteins. Human platelet antigens are derived from polymorphisms of these glycoproteins. The aim of this study was to investigate human platelet antigen frequencies in immune thrombocytopenia patients from the state of Amazonas, Brazil ...

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