In order to compare the clinical and microbiological efficacies and safety of piperacillin plus tazobactam with those of imipenem plus cilastatin, 134 patients with intra-abdominal infections (73 patients with appendicitis) participated in an open randomized comparative multicenter trial. A total of 40 men and 29 women (mean age, 53 years; age range, 18 to 92 years) were enrolled in the piperac...

The outer membrane permeability to meropenem and imipenem in Escherichia coli K-12 was investigated, and its porin-deficient mutants were transformed with a constructed vector carrying the carbapenem-hydrolyzing CphA metallo-beta-lactamase gene. By using the method of Zimmermann and Rosselet, meropenem was shown to penetrate through the outer membrane of E. coli K-12 five times faster than ceph...

CONTEXT Multiple surveillance programmes have reported a decline in antibiotic susceptibility of P. aeruginosa. AIM Our study aimed to study the relationship between the use of antipseudomonal drugs and the development of resistance of P. aerogenosa to these drugs. SETTING AND DESIGN Our study is retrospective. It was conducted in a medical surgical intensive care unit during a five-year pe...

background: recent analyses of hospital outbreaks have documented the spread of resistance to imipenem, which is cur­rently a major problem among gram positive and gram-negative bacteria. the aim of this study was to describe the rate of gram- positive and gram-negative isolates resistance to imipenem as an antibiotic. methods: recorded files of 242 hospitalized patients with at least one sampl...

BACKGROUND Cancer as a multistage process can be reversed or blocked by using chemopreventive agents. Colon cancer chemoprevention has been widely investigated using cyclooxygenase inhibitors and many other chemicals of synthetic or natural origin. This particular study was carried out to assess the colon cancer chemopreventive effect of hydro-methanol extract of Rumex abyssinicus rhizome on ra...

Background: Acinetobacter baumannii is one of the causes of nosocomial infections, especially in the intensive care unit. The emergence of multidrug-resistant strains of A. baumannii has caused many problems. One of the ways to handle the phenomenon of antibiotic resistance is the use of herbal medicines and their derivatives in place of or in combination with antibiotics. The aim of this study...

Background & Aims: Imipenem is a member of Carbapenem with stability against most -lactamases .It is of particular use in the treatment of infections associated with drug resistant gram negative bacteria harboring ESBL and AmpC genes. The aim of this study was to determine the imipenem resistance in gram negative bacteria causing nosocomial infections and the presence of metallo--lactamases (MB...

Purpose: To investigate the frequency of MBLs in Pseudomonas and Acinetobacter species with E-test, to determine risk factors evaluate demographic clinical features infected patients. Materials methods: Imipenem or meropenem resistance isolated from several samples conventional methods were evaluated imipenem EDTA E-test presence Metallo-β-lactameses MBL was examined. Several isolates screened ...