Leishmaniasis is considered one of the most untreated tropical diseases in world. In this study, we investigated vitro leishmanicidal activity and cytotoxicity various isolated lichen substances, including atranorin (1), usnic acid (2), gyrophoric (3), salazinic (4), galbinic (5), parietin (6), some semi-synthetic imine derivatives (7, 8, 9) (10, 11, 12, 13). Imine condensation reactions with h...

a mixture oftrimethylchlorosilane (tms-cl), lithium and tetrahydrofuran (thf) reacts with imines to produce disilyl compound by addition of two trimethylsilyl (tms) groups to the double bond of the imine. on hydrolysis the tms on nitrogen is substituted by hydrogen and yields ? -silylamine. in the presence of acetyl chloride (ch coc1), benzene and pyridine, the ?-silyamine produces the correspo...

in this research, an efficient synthesis toward 2-(2-((4-methoxybenzoyl)imino)-4-(4-methoxyphenyl)thiazol-3(2h)-yl)-2-phenylacetic acid via a three-component tandem reaction using aroylisothiocyanate, phenyl glycine, and 4-methoxyphenacyl bromide in an ionic liquid (il) has been described. 1-methyl-3-pentylimidazolium bromide (il) has been employed as a recyclable green solvent. the work-up pro...

Continuous-flow mass spectrometry (CFMS) was used to monitor the products formed during the initial 0.25-20 s of the reactions catalyzed by the flavoprotein N-acetylpolyamine oxidase (PAO) and the pterin-dependent enzymes phenylalanine hydroxylase (PheH) and tyrosine hydroxylase (TyrH). N,N'-Dibenzyl-1,4-diaminobutane (DBDB) is a substrate for PAO for which amine oxidation is rate-limiting. CFM...

A triazine based disc shaped molecule with two hydrolyzable units, imine and ester groups, was polymerized via acyclic diene metathesis in the columnar hexagonal (Colhex) LC phase. Fabrication of a cationic nanoporous polymer (pore diameter ∼1.3 nm) lined with ammonium groups at the pore surface was achieved by hydrolysis of the imine linkage. Size selective aldehyde uptake by the cationic poro...

An extremely rigid NNN-donor proligand, 4,5-bis{(diphenylmethylene)amino}-2,7,9,9-tetramethylacridan, H[AIm2] was prepared in five steps starting from 5-methyl-2-aminobenzoic acid and 4-bromotoluene. Reaction of intensely orange H[AIm2] with LiCH2SiMe3 formed deep blue Li(x)[AIm2]x (x = 2 in the solid state), while reaction with [Y(CH2SiMe3)3(THF)2] (0.5 equiv.) afforded deep blue [Y(AIm2)(AIm)...

Extracellular adenosine 5'-triphosphate (ATP) activates the P2X7 receptor channel to induce the rapid release of the proinflammatory cytokine, interleukin- (IL-) 1β, from macrophages. Microtubule rearrangements are thought to be involved in this process. Some isatin derivatives alter microtubules and display anticancer activities. The current study investigated the effect of isatin and seven st...

Genetic specificity information ―seen by‖ the transcriptase is in terms of hydrogen bonded proton states, which initially are metastable amino (–NH2) and, consequently, are subjected to quantum uncertainty limits. This introduces a probability of arrangement, keto-amino → enol-imine, where product protons participate in coupled quantum oscillations at frequencies of ~ 10 13 s −1 and are entangl...

Formation of carbinolamine, imine, and oxazolidines from the reactions of desisopropylpropranolol (5), its O-methyl ether (10), and 3-(1-naphthoxy)propylamine (11) with trifluoroacetone and trifluoroacetaldehyde methyl hemiacetal was investigated by F NMR and tandem mass spectrometry. Products from the metabolism of the related secondary amine substrates trifluoropropranolol (7), its O-methyl e...