Abstract Background/Aims Interleukin-17 inhibitors (anti-IL-17) have provided an additional treatment option in psoriatic arthritis (PsA). This study aims to describe the patient profile, patterns and persistence PsA patients treated with ixekizumab secukinumab a real-life setting. Methods A multicentre, retrospective was conducted at 8 Spanish hospitals. Three cohorts of adult patients, newly ...

Background: Scalp psoriatic itch is a prevalent yet understudied condition with numerous associated treatment challenges. Objective: The current study aims to enhance our understanding of scalp pathophysiology in order guide management and identify novel targets. Methods: Immunohistochemical analysis known neuroimmune mediators pruritus was conducted using biopsies from 27 patients psoriasis. P...

Abstract Background and Aims Mild cognitive impairment (MCI) consists of a decline one or more domains, independent functional impairment. There are common pathophysiological factors between chronic kidney disease (CKD) MCI. The aim this study was to evaluate the association MCI in pre-dialysis CKD with inflammation markers alterations image exams (Nuclear Magnetic Resonance-MRI). Method Cross-...

cytokines have important roles in the control of bacterial and viral infections such as hiv-1. interleukin 17 which is secreted by th17 is one of these cytokines with a special role in controlling microbial infections. in the present study, adjuvant activity of alum and naloxone mixture has been studied on immune responses, especially il-17 cytokine. naloxone and alum adjuvant are mixed with 10...