The presence of interleukin (IL)-17-related cytokines correlates with rheumatoid arthritis (RA) pathogenesis. Epigenetic modifications, including histone acetylation, regulate gene expression in RA pathogenesis. Tumour necrosis factor-alpha (TNF-α) inhibitors such as etanercept and adalimumab, represent a breakthrough in RA treatment. We aimed to investigate the effects of etanercept and adalim...

PURPOSE To investigate the role of T-cell-mediated immune response in a monophasic experimental autoimmune uveitis (EAU). METHODS A monophasic EAU was induced in Lewis rats by immunization with interphotoreceptor retinoid-binding protein peptide. Optimized quantitative real-time RT-PCR was used for consecutive measurement of the relative expression of Th17-associated molecules, including inte...

VITAMIN D is critical for calcium homeostasis (4). Recently, there is renewed interest in vitamin D because of experimental evidence indicating that 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], the hormonally active form of vitamin D, has numerous other functions, including immunomodulatory effects (6, 10). A role in immunity was suggested by early studies showing the presence of the vitamin D recep...

Recent studies have advanced our understanding of the pathophysiology autoimmune gastritis, particularly its molecular aspects. The most noteworthy recent advancement lies in identification several candidate genes implicated pathogenesis pernicious anemia through genome-wide association studies. These include PTPN22, PNPT1, HLA-DQB1, and IL2RA. also directed attention towards other such as ATP4...

IL-23 plays a critical role in EAE induced by the active immunization of C57BL/6 mice with an immunodominant epitope of myelin oligodendrocyte glycoprotein (MOG(35-55)). It was initially assumed that the pathogenic effects of IL-23 were directly related to the generation, expansion and/or stabilization of autoreactive CD4(+) Th17 cells. However, a number of recent studies have uncovered discrep...

Advances in knowledge regarding the pathogenesis of psoriasis have allowed the development of a new class of agents known as biologic drugs. Data confirm that T helper (Th)17 and interleukin (IL)-17 signaling has a crucial role in the pathogenesis of the disease. High levels of IL-17 and Th17-related cytokines have been reported in psoriasis, leading to the suggestion of agents targeting IL-17 ...

IL-17-producing T lymphocytes have been recently shown to comprise a distinct lineage of proinflammatory T helper cells, termed Th17 cells, that are major contributors to autoimmune disease. We show here that the orphan nuclear receptor RORgammat is the key transcription factor that orchestrates the differentiation of this effector cell lineage. RORgammat induces transcription of the genes enco...