Objective To review the clinical/oncological presentations of gamma aminobutyric acid-B receptor (GABABR)-IgG and evaluate clinical specificity antibody testing methodologies. Background GABABR-IgG is an intermediate-risk paraneoplastic autoantibody commonly associated with encephalitis and/or seizures. Design/Methods positive patients tested at Mayo Clinic Neuroimmunology Laboratory were ident...

Treatment of covalently cross-linked or heat-aggregated oligomers of human IgG with 4 mMtetranitromethane abrogated their Clq-binding activity. In contrast, tetranitromethane modification of rabbit IgG oligomers, under identical conditions, had no effect upon their Clq-binding activity. The tetranitromethane treatment led to nitration of about ten tyrosine residues per IgG molecule in both spec...

Three experiments were conducted including 180 Majorera kids. In the first experiment, the effect of use of lyophilized colostrum vs. frozen colostrum on immunoglobulin G (IgG) blood serum concentration was evaluated. Kids (n = 40) received the same management and IgG mass [3368 mg/kg of body weight (BW)] during the colostrum feeding period. The IgG in blood serum of kids from the lyophilized c...

BACKGROUND Abnormal intrathecal synthesis of IgG, reflected by cerebrospinal fluid (CSF) oligoclonal IgG bands (OBs) and increased IgG index, is much less frequently observed in Japanese multiple sclerosis (MS) cohorts compared with Western cohorts. We aimed to clarify whether genetic and common infectious backgrounds influence CSF IgG abnormality in Japanese MS patients. METHODOLOGY We analy...

Objective(s) The immunoadjuvant potential of cross-linked dextran microspheres (CDM) as absorption enhancer and Quillaja saponins (QS) as immunomodulator adjuvant was evaluated. Materials and Methods CDM loaded or tetanus-mixed toxoid (TT) or Quillaja saponin (QS) were nasally administered to rabbits in dry powder form, three times in 2 weeks interval and serum IgG and nasal lavage sIgA tite...