intestinal parasitosis has been a major public health problem in iran. it is necessary to evaluate an up-date data in this regard to be used by local authorities. serum ige determinations and coproparasitological analyses were conducted on 1200 individuals in city of ghaemshahr, mazandaran province, northern iran. a total of 1200 subjects were taken stool samples for three days consecutively. t...

Lithospermum erythrorhizon (L. erythrorhizon) root is used in traditional medicine for its anti-inflammatory, antibacterial, and antioxidant properties. However, no studies have examined impact on allergic rhinitis (AR). Here, we explored the protective effects of L. immunoglobulin E (IgE)-stimulated RBL-2H3 cells an ovalbumin (OVA)-induced AR mouse model. In latter, nasal mucosal inflammation,...

BACKGROUND Chronic spontaneous urticaria (csU), which is characterized by recurrent episodes of mast cell-driven wheal and flare-type skin reactions, is often associated with elevated total IgE levels and thyroid autoimmunity. We speculate that some csU patients express IgE autoantibodies against thyroid antigens such as thyroid peroxidase (TPO), which could bind to skin mast cells and induce t...

BACKGROUND Recent studies have confirmed the presence of viable Chlamydia in the bronchoalveolar lavage (BAL) fluid of pediatric patients with airway hyperresponsiveness. While specific IgG and IgM responses to C. pneumoniae are well described, the response and potential contribution of Ag-specific IgE are not known. The current study sought to determine if infection with Chlamydia triggers the...

BACKGROUND Cow's milk (CM) is one of the most common food allergens in children with atopic dermatitis (AD), and the component-specific immunoglobulin E (component-IgE) measurement has recently become available. OBJECTIVE This study aimed to investigate the sensitization patterns to CM and 3 major components and their clinical values in young Korean children with AD. METHODS Cow's milk-spec...

Antilipopolysaccharide (anti-LPS) immunoglobulin G (IgG) and IgM have been associated with protection from LPS effects in vivo. We investigated the presence of IgE and anti-LPS in 32 patients that had experienced severe traumatic injury and in 35 healthy volunteers; we also investigated whether IgE anti-LPS was associated with important clinical events. Plasma samples were collected daily from ...

Abstract Immunoglobulin E (IgE) is the primary cause of allergic diseases and must be tightly regulated. Production IgE occurs when activated B cells undergo class switch recombination (CSR) to IgE. These key events are rare, thus questions on which cell subsets CSR, where CSR predominantly occurs, molecular cellular signals promote remain unresolved. We modeled asthma by intranasal administrat...