نتایج جستجو برای: idiopathic pulmonary arterial hypertension ipah
تعداد نتایج: 480229 فیلتر نتایج به سال:
Objectives: To characterize the demographic and clinical profiles of patients with Idiopathic Pulmonary Arterial Hypertension (IPAH) admitted to the tertiary care hospital in Aseer region, and to evaluate the altitude effect. Design: A retrospective cohort study. Setting: Aseer Central Hospital. Subjects: All patients admitted with the diagnosis of (IPAH) during the period from January 2001 to ...
Chronic thromboembolic pulmonary hypertension (CTEPH) has been increasingly recognized as a common source of elevated pulmonary vascular resistance and pulmonary hypertension. It is clear that development of pulmonary thromboemboli is the inciting event for this process, yet it remains unclear why some patients have persistent pulmonary artery occlusion leading to distal pulmonary vascular remo...
Pulmonary hypertension (PH), defined as a mean pulmonary arterial (PA) pressure of >25 mmHg at rest or >30 mmHg during exercise, is characterized by a progressive and sustained increase in pulmonary vascular resistance that eventually leads to right ventricular failure. Clinically, PH may result from a variety of underlying diseases (Table 1 and Refs. 50, 113, 124). Pulmonary arterial hypertens...
The treatment of pulmonary arterial hypertension (PAH) is directed at the underlying cause, such as diastolic heart failure or chronic thromboembolic disease. Patients with idiopathic PAH or PAH associated with connective-tissue disease who have World Health Organization (WHO) functional class II or III PAH should receive a trial of oral bosentan, ambrisentan, and/or sildenafil; inhaled ilopros...
BACKGROUND Excessive proliferation of pulmonary artery smooth muscle cells (PASMCs) plays an important role in the development of idiopathic pulmonary arterial hypertension (IPAH), whereas a rise in cytosolic Ca2+ concentration triggers PASMC contraction and stimulates PASMC proliferation. Recently, we demonstrated that upregulation of the TRPC6 channel contributes to proliferation of PASMCs is...
BACKGROUND Idiopathic pulmonary arterial hypertension (IPAH) is a devastating disease characterized by increased pulmonary vascular resistance, smooth muscle and endothelial cell proliferation, perivascular inflammatory infiltrates, and in situ thrombosis. Circulating intravascular ATP, ADP, AMP and adenosine activate purinergic cell signaling pathways and appear to induce many of the same path...
Excessive proliferation of pulmonary arterial smooth muscle cells (PA-SMCs) and perivascular inflammation lead to pulmonary arterial hypertension (PAH) progression, but they are not specifically targeted by the current therapies. Since leptin (Ob) and its main receptor ObR-b contribute to systemic vascular cell proliferation and inflammation, we questioned whether targeting Ob/ObR-b axis would ...
BACKGROUND Decline in oxygen uptake efficiency (OUE), especially during exercise, is found in patients with chronic heart failure. In this study we aimed to test the validity and usefulness of OUE in evaluating gas exchange abnormality of patients with idiopathic pulmonary arterial hypertension (IPAH). METHODS We retrospectively investigated the cardiopulmonary exercise test (CPET) with gas e...
M ore than 50 yrs ago, DRESDALE et al. [1] reported a series of 39 patients with unexplained pulmonary hypertension and coined the term ‘‘primary pulmonary hypertension’’ to describe the condition, a term that has been revised to ‘‘idiopathic pulmonary arterial hypertension’’ in the most recent classification [2]. Idiopathic pulmonary arterial hypertension is a disease of the small pulmonary ar...
ulmonary hypertension (PH) is a condition that not only causes many problems for those suffering from it, but also can exacerbate and complicate many other diseases. PH can be responsible for mortality in many patients. Tackling PH is not exclusively related to the field of cardiovascular diseases. Many other diseases in other fields of medicine may interfere with PH. Pulmonary diseases, renal,...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید