BACKGROUND Antiepileptic drugs have been reported to affect cerebral metabolism. We performed (18)F-fluorodeoxyglucose positron emission tomography (PET) before and after lamotrigine administration to investigate its effects on cerebral glucose metabolism in patients with drug-naïve idiopathic generalized epilepsy. DESIGN We included patients who were newly diagnosed as having idiopathic gene...

PURPOSE Epilepsy can develop at any age for reasons that remain poorly understood. The aim of this study was to determine the impact of a family history of epilepsy (FHE) on the incidence and recurrence of seizures. METHODS This retrospective study was conducted in Aseer central hospital, Abha, Saudi Arabia between January and June 2012. The medical records of 420 patients were analyzed to te...

Phenylketonuria (PKU) is characterized by phenylalanine accumulation due to phenylalanine hydroxylase deficiency. Up to 50% of PKU patients experience seizures. We evaluated an adult PKU patient who suffered from absences and primarily generalized tonicclonic seizures, associated with generalized spikeand-wave discharges (GSWs) on EEG. An analysis of blood oxygenation level-dependent (BOLD) sig...

Mr. X and that of the author. The history of Mr. X has been kept by himself with painstaking accuracy and much insight for about thirty years. The clinical value of these remarkable observations is greatly increased by a report upon them from that amazing genius, Hughlings Jackson. In this connection we may be permitted to observe how entirely we support the author's contention that it is discr...

Epilepsy is the most common neurological disease seen in dogs, affecting up to five percent of the canine population. However, this statistic is somewhat misleading as epilepsy is not a single disease. Instead, the diagnosis of epilepsy potentially refers to any one of a number of conditions that are characterized by the presence of chronic, recurring seizures. These conditions may be inherited...